tag:blogger.com,1999:blog-253935367472472272024-02-28T23:42:37.610+00:00Daria BlackwellA writer's journey into publishingDaria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.comBlogger140125tag:blogger.com,1999:blog-25393536747247227.post-56957053918449905022023-12-26T16:23:00.005+00:002023-12-27T17:57:31.910+00:00Living through 2023<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi1OezOsW69DHRy6GfZx4De28to34bHGJpi87R1BSI63Q2AAeO4MQtB-WO1ubpmjokLMMn4zVi_2VdKBSGO7TDm1j8rT_0xysD5UGiRiEYu6opiAI88wZO3lC_DNmhrorgDQPV5LYTB2KPtN0gzu76AoJ6RZsOf-rV1UEDNa8cK043LcJ08rXR_vjFH1G4/s1600/13355179_060723-kgo-empire-state-building-orange-img.jpg" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="900" data-original-width="1600" height="225" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi1OezOsW69DHRy6GfZx4De28to34bHGJpi87R1BSI63Q2AAeO4MQtB-WO1ubpmjokLMMn4zVi_2VdKBSGO7TDm1j8rT_0xysD5UGiRiEYu6opiAI88wZO3lC_DNmhrorgDQPV5LYTB2KPtN0gzu76AoJ6RZsOf-rV1UEDNa8cK043LcJ08rXR_vjFH1G4/w400-h225/13355179_060723-kgo-empire-state-building-orange-img.jpg" width="400" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">NYC during Canada's forest fires</td></tr></tbody></table><br /><p>It's hard to know if this was the best year of the coming decade, but if it was, beware. What did it do for us? High anxiety. Climate anxiety or eco-anxiety is a new human condition, and it's real and pervasive. </p><p>Weather weirdness and climate breakdown. Drought, fires, and floods. So sad for the forests of Canada and the beautiful historic Lahaina. Records broken for air and sea temperature anomalies, ice formation, and more. Floods after drought. Extreme weather causing massive devastation, crop failures, mass migration, and starvation. Food and water insecurity. The extinction rebellion. COP28 in the UAE led by an oil CEO Sultan. </p><p>Wars on many fronts: Ukraine-Russia, Israel-Palestine, Sudan, Ethiopia, Maghreb. </p><p>The Barbenheimer phenomenon. What was that? A bit of escapism in a tug-of-war with weapons of mass destruction. </p><p>Trump and Guiliani would be jokes if they weren't so dangerous. This signals the downfall of democracy in America. Stress on so many fronts. The states warring with each other. The US passing a point of no return. </p><p>Humanity at war with the earth, and with each other. </p><p>Were there any high points? Of course. We rekindled relationships post-Covid, including with our cousins in Florida. But there are a few positives to which we can point for hope. </p><p></p><ul style="text-align: left;"><li>Renewables have been picking up steam</li><li>Phasing out of fossil fuels made it into the COP28 agreements</li><li>Reduction in the rate of release of methane</li><li>Surge in sales of EVs</li><li>Reduction in deforestation of Brazil</li><li>The ozone layer is healing well</li></ul><div>But on that last point, a <a href="https://www.washingtonpost.com/climate-environment/2023/12/26/global-warming-accelerating-climate-change/?utm_campaign=wp_the7&utm_medium=email&utm_source=newsletter&wpisrc=nl_the7" target="_blank">study</a> has been published that indicates that global warming is accelerating due to one simple fact: we have been cleaning up particulate matter from the air which unbeknownst to us had a cooling effect on the earth. Now that the air is cleaner, more sunlight is getting through to warm the earth even faster. </div><div><br /></div><div>So we are f*^%ed ... we can die either from pollution-related respiratory disease or from melanoma or heat stroke. Charming thoughts. </div><div><br /></div><div>While there's much to be worried about the climate and nature crises, we must not lose hope, because hopelessness breeds apathy. Hope alone won't change anything but actions do. We built a big shed. We've contracted to install solar panels, batteries, and an eV charging point early in the new year. An eV will follow shortly thereafter. Hey, it's a start. We've planted hundreds of trees, and we don't use chemicals on the land. We encourage biodiversity and provide wildlife with habitat. Perhaps we can encourage others to do the same. </div><div><br /></div><div><div><br /></div><div><br /></div></div><p></p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-23898832345062305712023-12-23T18:40:00.003+00:002023-12-23T18:40:24.887+00:00Caroling at the Dali Museum, Tampa FL<p style="text-align: center;"> <iframe allowfullscreen='allowfullscreen' webkitallowfullscreen='webkitallowfullscreen' mozallowfullscreen='mozallowfullscreen' width='320' height='266' src='https://www.blogger.com/video.g?token=AD6v5dzaWzTMtFsaYUV_yhQgDz56YA17G1PH0gd21NgLFKfwBStKqrj6r_lfm3e5wTMLps04PDHKhld4U7FUtCfA' class='b-hbp-video b-uploaded' frameborder='0'></iframe></p><p style="text-align: center;">Христос рождается!</p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-430434319508887452023-12-18T10:47:00.004+00:002023-12-18T10:47:50.364+00:00 The world’s gone mad<p><b><span style="font-size: large;">The world’s gone mad</span></b></p><p>by Daria Blackwell</p><p><br /></p><p>We fight a daily battle against prejudice</p><p>With wars on many fronts taking lives</p><p>That might have been the ones to solve</p><p>The other problems we are facing.</p><p>Like climate weirdness, fire and flood,</p><p>And food insecurity for all those masses. </p><p>Humanity has reached its life expectancy</p><p>And we will soon outlive our resources.</p><p>I wonder if God foresaw this issue.</p><p>I wonder if it matters that the world’s gone mad?</p><div><br /></div>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-62460286708016322892023-11-08T19:45:00.002+00:002023-11-09T10:45:41.636+00:00The River<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEimxTy9XfZcoi9Jp-wKb6HqZSTBqRb_Ejo0I2u4ESGiv38tu_ZP66kRksIp6tCgOg3yCTw8JpuRZJ_Uc2GrDHz3_BD8A1ilyZpIarXUt_ZE-p5x1kLRv65ddtkBcaKeuDge1NPYW47u275hV-K5waw8J52l7yiHLOQJ-McSzMmagN8P0D6z0UjLo57_Ok0/s4624/20231029_091142.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="4624" data-original-width="3468" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEimxTy9XfZcoi9Jp-wKb6HqZSTBqRb_Ejo0I2u4ESGiv38tu_ZP66kRksIp6tCgOg3yCTw8JpuRZJ_Uc2GrDHz3_BD8A1ilyZpIarXUt_ZE-p5x1kLRv65ddtkBcaKeuDge1NPYW47u275hV-K5waw8J52l7yiHLOQJ-McSzMmagN8P0D6z0UjLo57_Ok0/s320/20231029_091142.jpg" width="240" /></a></div><br /><p><br /></p><p><b><span style="font-size: medium;">The River</span></b></p><p>We can't blame the river for flowing</p><p>We can't hate the wild wind blowing</p><p>We can't stop time from advancing</p><p>And we can't prevent what's coming. </p><p><br /></p><p>The end. </p><p><br /></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjxy2I8K5Nh9UEeBwFXzU3p7mExGh7wtzb8vKEdpQ7Scp5oCWKMjADWAG5W-fmcg_psnPWV7OjcNNNnQTW64R_ZQ99P6zDLpgUDxiMcB7XBUMLfZJonEjxgSn5_n3lmPOVFsISHVxP1_nI9exvFRs7uXmcZHlAldhdO-MiI5HMtiKfpAJ9_nACY4piOZEk/s4624/20231029_130745.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="3468" data-original-width="4624" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjxy2I8K5Nh9UEeBwFXzU3p7mExGh7wtzb8vKEdpQ7Scp5oCWKMjADWAG5W-fmcg_psnPWV7OjcNNNnQTW64R_ZQ99P6zDLpgUDxiMcB7XBUMLfZJonEjxgSn5_n3lmPOVFsISHVxP1_nI9exvFRs7uXmcZHlAldhdO-MiI5HMtiKfpAJ9_nACY4piOZEk/s320/20231029_130745.jpg" width="320" /></a></div><br /><p><br /></p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-44667090963681224962023-07-02T11:51:00.005+01:002023-10-08T11:11:40.627+01:00Planning for the future<div><div>“To the well-organized mind, death is but the next great adventure.”</div><div style="text-align: right;">-Albus Dumbledore</div></div><div><br /></div>Four songs for the final scenes. <span style="font-size: large;"><b><div><span style="font-size: large;"><b><br /></b></span></div>Landslide</b></span><div>by Stevie Nicks <span style="font-size: large;"><b><br /></b></span><br />I took my love, I took it down<br />I climbed a mountain and I turned around<br />And I saw my reflection in the snow-covered hills<br />'Til the landslide brought me down<div><br />Oh, mirror in the sky<br />What is love?<br />Can the child within my heart rise above?<br />Can I sail through the changin' ocean tides?<br />Can I handle the seasons of my life?</div><div><br />Well, I've been afraid of changin'<br />'Cause I've built my life around you<br />But time makes you bolder<br />Even children get older<br />And I'm getting older too</div><div><br />Well, I've been afraid of changin'<br />'Cause I've built my life around you<br />But time makes you bolder<br />Even children get older<br />And I'm getting older too</div><div>Oh! I'm getting older too</div><div><br />Oh-oh, take my love, take it down<br />Oh-oh, climb a mountain and you turn around<br />And if you see my reflection in the snow-covered hills<br />Well, the landslide'l bring it down<br />And if you see my reflection in the snow-covered hills<br />Well, the landslide'l bring it down<br /><br />Oh-ohh, the landslide bring it down<p><b><span style="font-size: large;"><br /></span></b></p><p><b><span style="font-size: large;">Spirit in the sky</span></b></p><p>by Norman Greenbaum</p><br />When I die and they lay me to rest<br />Gonna go to the place that's the best<br />When I lay me down to die<br />Goin' up to the spirit in the sky<br />Goin' up to the spirit in the sky<br />That's where I'm gonna go when I die<br />When I die and they lay me to rest<br />Gonna go to the place that's the best<br /><br /><br />Prepare yourself you know it's a must<br />Gotta have a friend in Jesus<br />So you know that when you die<br />He's gonna recommend you<br />To the spirit in the sky<br />Gonna recommend you<br />To the spirit in the sky<br />That's where you're gonna go when you die<br />When you die and they lay you to rest<br />You're gonna go to the place that's the best<br /><br /><br />Never been a sinner I never sinned<br />I got a friend in Jesus<br />So you know that when I die<br />He's gonna set me up with<br />The spirit in the sky<br />Oh set me up with the spirit in the sky<br />That's where I'm gonna go when I die<br />When I die and they lay me to rest<br />I'm gonna go to the place that's the best<br />Go to the place that's the best<p><br /></p><p><b><span style="font-size: large;"><br />Here Beside Me</span></b><br /><br />by the Henry Girls<br />with Inishowen Gospel Choir<br /><br /></p>You with me, here beside me</div><div>Is all I really need<br />I'm asking one thing only<br />That you will always stay close to me<br /><br />I will be true, in sunshine and shade<br />Troubles behind no longer dismayed<br />I'm going back to the mountain<br />It's where I long to be<br /><br />You with me, here beside me<br />Is all I really need<br />I'm asking one thing only<br />That you will always stay close to me<br /><br />I will be true, in sunshine and shade<br />Troubles behind no longer dismayed<br />I'm going back to the mountain<br />Where I long to be<br /><br />I'm going back to the ocean<br />To put my mind at ease<p><br /></p><div class="USiT3d" style="background-color: white; color: #202124; display: flex; font-family: arial, sans-serif;"><div class="Ailvgd" style="flex: 1 1 0%;"><div data-hveid="CBMQAA" data-ved="2ahUKEwj7ke2JleaBAxVtVUEAHYnfCIMQlcAGegQIExAA"><div class="KsRP6" style="display: flex;"><div class="MDY31c"><div class="QpPSMb" style="align-items: center; display: flex;"><div class="DoxwDb"><a class="a3glFf oRJe3d" data-ti="default_tab:kc:/music/recording_cluster:lyrics" data-ved="2ahUKEwj7ke2JleaBAxVtVUEAHYnfCIMQ_coHegQIExAD" jsaction="rcuQ6b:npT2md;KjsqPd" jscontroller="PCqCoe" jsname="L3GAnc" role="link" style="-webkit-tap-highlight-color: rgba(0, 0, 0, 0.1); cursor: pointer; outline: 0px; text-decoration-line: underline;" tabindex="0"><div aria-level="2" class="PZPZlf ssJ7i B5dxMb" data-attrid="title" role="heading" style="font-family: "Google Sans", arial, sans-serif-medium, sans-serif; font-size: 20px; line-height: 26px; word-break: break-word;">I’ll Fly Away</div></a></div><span class="yyFhVb z1asCe GNeCNe" style="color: #70757a; display: inline-block; fill: currentcolor; flex-shrink: 0; height: 32px; line-height: 32px; position: relative; width: 32px;"><svg focusable="false" viewbox="0 0 24 24" xmlns="http://www.w3.org/2000/svg"><path d="M10 6L8.59 7.41 13.17 12l-4.58 4.59L10 18l6-6z"></path></svg></span></div><div class="nwVKo" style="align-items: center; display: flex;"><div class="loJjTe"><div aria-level="3" class="iAIpCb PZPZlf" data-attrid="subtitle" role="heading" style="color: #4d5156; font-size: 14px; line-height: 20px; margin-top: 2px;">by Alan Jackson</div></div><div class="r2VLS WAvXif"><div data-ias="false" jsaction="oqw9D:j0y2Xe" jscontroller="rhe7Pb"><div class="y1yadf" style="display: inline-block; position: relative; z-index: 125;"><g-dropdown-menu jsaction="rcuQ6b:npT2md;mMf61e:GKlhgf;YraOve:cCpuJc;kNOP9c:bzkPEc;hmb6Ye:oyYkKb;KyPa0e:G8Ofmd;wjOG7e:rWoVB;ZvRO4b:L76sMb;LyWNEf:L76sMb" jscontroller="pFsdhd" jsdata="xJGXK;_;B+vVmw" jsname="tcAyJf" jsshadow="" style="display: inline-block; position: relative; vertical-align: middle;"><g-popup __is_owner="true" class="eNRwyf" id="ow41" jsaction="A05xBd:IYtByb;EOZ57e:WFrRFb;" jscontroller="DPreE" jsdata="mVjAjf;_;B+vVm0" jsname="zpo2ue" style="height: 100%; width: 100%;"><div aria-expanded="false" aria-haspopup="true" class="CcNe6e v4Zpbe" fdprocessedid="rlrnho" jsaction="WFrRFb;keydown:uYT2Vb" jsname="oYxtQd" jsslot="" role="button" style="cursor: pointer; display: flex; height: 20px; outline: 0px; width: 20px;" tabindex="0"><span aria-label="More options" class="XQIMve wSFoM ZS5sq IzqbHb z1asCe SaPW2b" data-ved="2ahUKEwj7ke2JleaBAxVtVUEAHYnfCIMQ0-wHegQIExAG" style="border-radius: 50%; display: inline-block; fill: currentcolor; height: 16px; line-height: 16px; padding: 2px; position: relative; width: 16px;"><svg focusable="false" viewbox="0 0 24 24" xmlns="http://www.w3.org/2000/svg"><path d="M12 8c1.1 0 2-.9 2-2s-.9-2-2-2-2 .9-2 2 .9 2 2 2zm0 2c-1.1 0-2 .9-2 2s.9 2 2 2 2-.9 2-2-.9-2-2-2zm0 6c-1.1 0-2 .9-2 2s.9 2 2 2 2-.9 2-2-.9-2-2-2z"></path></svg></span></div></g-popup></g-dropdown-menu></div></div></div></div></div></div></div></div><ul class="VABr3b" data-hveid="CA0QBQ" style="list-style-type: none; margin: 0px; padding: 0px;"><li class="LfE12c" style="background-color: #e5edff; border-radius: 100px; color: #001c39; display: inline-block; margin: 0px 8px 12px 0px; max-width: calc(100% - 24px); overflow: hidden; padding: 10px 16px; position: relative; text-overflow: ellipsis; text-wrap: nowrap;"><div class="LFmEI" style="border-radius: 100px; color: #c7dbff; cursor: pointer; height: 45.2656px; left: 0px; position: absolute; top: 0px; width: 140.547px;"><br /></div></li></ul></div><div style="background-color: white; color: #202124; font-family: arial, sans-serif;"><div class="Kot7x"><div data-hveid="CA0QCg" data-lopri="1" data-rcov="1" data-ved="2ahUKEwj7ke2JleaBAxVtVUEAHYnfCIMQydoBKAB6BAgNEAo" id="kp-wp-tab-cont-default_tab:kc:/music/recording_cluster:lyrics" jsaction="rcuQ6b:npT2md;u16dZe:h1apBe;lgrA4c:LZRHNc;sQFYsc:J0vfUe;Vituk:iBD8fc;VWEuHf:Hh7WQb" jscontroller="etGP4c" jsdata="gsRMGb;_;B+vVms"><div class="xDKLO" style="padding-top: 0px;"><div data-hveid="CBQQAA" data-ved="2ahUKEwj7ke2JleaBAxVtVUEAHYnfCIMQkt4BKAB6BAgUEAA" id="kp-wp-tab-default_tab:kc:/music/recording_cluster:lyrics"><div class="TzHB6b cLjAic LMRCfc" data-hveid="CBkQAA" data-ved="2ahUKEwj7ke2JleaBAxVtVUEAHYnfCIMQy9oBKAB6BAgZEAA" jsdata="PhoHd;_;B+vVnI" style="font-size: 14px; margin: 0px;"><div jsname="xQjRM"><div class="sATSHe"><div class="wDYxhc NFQFxe" data-attrid="kc:/music/recording_cluster:lyrics" data-md="113" style="clear: none;"><div data-hveid="CBYQAA" data-ved="2ahUKEwj7ke2JleaBAxVtVUEAHYnfCIMQsEx6BAgWEAA"><div class="Z1hOCe"><div class="PZPZlf zloOqf" data-lyricid="Musixmatch267551"><div class="xaAUmb" style="line-height: 20px; margin: 16px;"><div jsname="Vinbg"></div><div jsname="WbKHeb"><div class="ujudUb" jsname="U8S5sf" style="margin-bottom: 12px;"><span jsname="YS01Ge">Some glad morning when this life is over</span><br aria-hidden="true" /><span jsname="YS01Ge">I'll fly away</span><br aria-hidden="true" /><span jsname="YS01Ge">To a home on God's celestial shore</span><br aria-hidden="true" /><span jsname="YS01Ge">I'll fly away</span></div><div class="ujudUb" jsname="U8S5sf" style="margin-bottom: 12px;"><span jsname="YS01Ge">I'll fly away, oh, Glory</span><br aria-hidden="true" /><span jsname="YS01Ge">I'll fly away</span><br aria-hidden="true" /><span jsname="YS01Ge">When I die, Hallelujah, by and by</span><br aria-hidden="true" /><span jsname="YS01Ge">I'll fly away</span></div><div class="ujudUb" jsname="U8S5sf" style="margin-bottom: 12px;"><span jsname="YS01Ge">Just a few more weary days and then</span><br aria-hidden="true" /><span jsname="YS01Ge">I'll fly away</span><br aria-hidden="true" /><span jsname="YS01Ge">To a land where joy shall never end</span><br aria-hidden="true" /><span jsname="YS01Ge">I'll fly away</span></div><div class="ujudUb" jsname="U8S5sf" style="margin-bottom: 12px;"><span jsname="YS01Ge">I'll fly away, oh, Glory</span><br aria-hidden="true" /><span jsname="YS01Ge">I'll fly away</span><br aria-hidden="true" /><span jsname="YS01Ge">When I die, Hallelujah, by and by</span><br aria-hidden="true" /><span jsname="YS01Ge">I'll fly away</span></div><div class="ujudUb WRZytc" jsname="U8S5sf" style="margin-bottom: 0px;"><span jsname="YS01Ge">Yeah, when I die, Hallelujah, by and by</span><br aria-hidden="true" /><span jsname="YS01Ge">I'll fly away</span></div><div class="ujudUb WRZytc" jsname="U8S5sf" style="margin-bottom: 0px;"><span jsname="YS01Ge"><br /></span></div><div class="ujudUb WRZytc" jsname="U8S5sf" style="margin-bottom: 0px;"><span jsname="YS01Ge">The Kossoy Sisters https://www.youtube.com/watch?v=juHtN7hjtc4 </span></div><div class="ujudUb WRZytc" jsname="U8S5sf" style="margin-bottom: 0px;"><span jsname="YS01Ge">Alison Krauss & Gillian Welch https://www.youtube.com/watch?v=uz-0C2dhKlg </span></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-52942065959935180642023-06-30T16:24:00.002+01:002023-07-30T12:03:28.020+01:00 On Turning 69<p><span style="font-size: large;">On Turning 69</span></p><p class="MsoTitle"><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">By Daria Blackwell<o:p></o:p></p>
<p class="MsoNormal">29 June 2023<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Today is my day to reflect on the number<o:p></o:p></p>
<p class="MsoNormal">That, in my youth, induced smirks and blushes<o:p></o:p></p>
<p class="MsoNormal">But in my new age means something<o:p></o:p></p>
<p class="MsoNormal">Altogether different, finite and surreal. <o:p></o:p></p>
<p class="MsoNormal">I never thought I’d live this long – <o:p></o:p></p>
<p class="MsoNormal">Flower children of the ‘70s never did. <o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">But as I sit here on top of my world, <o:p></o:p></p>
<p class="MsoNormal">I can see beyond the hills in both directions<o:p></o:p></p>
<p class="MsoNormal">And beyond the sea to my humble beginning.<o:p></o:p></p>
<p class="MsoNormal">I look up and view the future in the clouds<o:p></o:p></p>
<p class="MsoNormal">And look down to see the imprint of this day. <o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">What have I accomplished, where have I been?<o:p></o:p></p>
<p class="MsoNormal">Who have I touched, what have I learned?<o:p></o:p></p>
<p class="MsoNormal">Does it matter in the end to amass achievements?<o:p></o:p></p>
<p class="MsoNormal">Material things: a house, a boat, a life well-lived?<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Do adventures matter, should I pursue more?<o:p></o:p></p>
<p class="MsoNormal">Is there still more to learn from that yet to come?</p><p class="MsoNormal">Questions I’d have thought would’ve been answered by now. </p><p class="MsoNormal"><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">But no, I find only more questions about questions,<o:p></o:p></p>
<p class="MsoNormal">Until I can rest and collect my thoughts in patterns.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">This satisfies my soul and sets my mind finally to rest. <o:p></o:p></p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-11023963466852706772023-05-03T18:07:00.005+01:002023-05-03T18:07:51.906+01:00Reflections of an introvert<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiB93xFlEYXFIFiXudjuUhzPolSCgZ4HnyBc8Dis7VaRzZEo4zZPHPCO9q9MKifYuc8UjYpVm1EgKu0rMirwNOOWlqT7Tu7YFg7xK9oWSC8I4ACQW1jEikyf2WUCAAy30sDcWWGEqyLckha8AoNGNIHwGMxggmGrKH89oTyzCyrLzdpVq_66F8MF7o3/s1848/OCCAwardBlackwell.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="1408" data-original-width="1848" height="244" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiB93xFlEYXFIFiXudjuUhzPolSCgZ4HnyBc8Dis7VaRzZEo4zZPHPCO9q9MKifYuc8UjYpVm1EgKu0rMirwNOOWlqT7Tu7YFg7xK9oWSC8I4ACQW1jEikyf2WUCAAy30sDcWWGEqyLckha8AoNGNIHwGMxggmGrKH89oTyzCyrLzdpVq_66F8MF7o3/s320/OCCAwardBlackwell.jpg" width="320" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">My last day as OCC Vice Commodore, receiving the OCC Award</td></tr></tbody></table><p>It's interesting that I haven't written anything in 2023 yet and it is already 3 May. I haven't been writing much. I have been gardening quite a bit lately, and working with the Ukrainian community.</p><p>What I have been doing mostly is figuring out how I can rid myself of all these responsibilities I have taken on. I started with the Ocean Cruising Club Vice Commodore's spot, which I gave up at the AGM in Poole UK last month. I had reached a point where I had little interest (much like happened with HBA), after having done a lot during the pandemic years. For which I was honoured with the OCC Award (much like the STAR award with HBA). I seem to be following a pattern. </p><p>I wonder what interest the next decade will bring? I'm betting on viticulture and winemaking. </p><p>We have finally reached close to the end of cleaning out Ross House, for which I am grateful as that took a lot of time and effort. Every Monday for almost a year, Kirsten and I have been clearing out 170 years of family stuff, room by room. The piles -- goes with house, one of us keeps, goes to charity, goes to the dump. We've taken truckloads to charity and more truckloads to the dump. We've also distributed some stuff among our homes, which are now brimming with stuff in turn. But as probate is not yet concluded, we cannot move on. It's very frustrating that it's all dragging. </p><p>Chris and Marika and Aileen and Sheila were here briefly to finalise some things. It was good seeing them and getting to know their partners. Everyone is getting up there in age.</p><p>I now have to figure out how to get my introvert life back from the Ukrainians. I have helped several families all of whom want to thank me profusely. I took on the more difficult cases because I could help with language and maneuvering through the systems. But now, its time to move on and they do not understand. </p><p>I seem to be getting more introverted as I get older, perhaps because there's little I need to achieve at this point. I am comfortable in my own skin, I do not need conversation, I am happy with my life. What more is there? More wisdom? More awards? No, time to go spend some money while I still can. At least then, I will learn finally, if money can buy happiness. Until now, I haven't allowed that to happen. </p><p><br /></p><p><br /></p><p> </p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-26105832581113896332022-12-27T13:07:00.001+00:002022-12-27T13:07:13.040+00:00Out of the funk<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjnnyRdiy9Zg3BIWOZzO-YX77UnkpQsFU5uecUoNYUKt1yE7k7o97_C4bNljPl7hztwq2iXqxXJyOBo2pzd4IwSzkDm2P-lrc4vFeDLrL4vOnujioJDSGn7wB02plu55FeslQZekBA4eTLCiEm1ED2GOVmGh__Lw5-cfHabBz4JuUd9KsjwJ6T5kH6F/s1156/WhatsApp%20Image%202022-12-22%20at%2012.31.34.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="867" data-original-width="1156" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjnnyRdiy9Zg3BIWOZzO-YX77UnkpQsFU5uecUoNYUKt1yE7k7o97_C4bNljPl7hztwq2iXqxXJyOBo2pzd4IwSzkDm2P-lrc4vFeDLrL4vOnujioJDSGn7wB02plu55FeslQZekBA4eTLCiEm1ED2GOVmGh__Lw5-cfHabBz4JuUd9KsjwJ6T5kH6F/s320/WhatsApp%20Image%202022-12-22%20at%2012.31.34.jpg" width="320" /></a></div><br /><p>I came out of the funk just at the end of November. Was there a trigger? Not that I know of. But I do recognise that it was a form of depression. Anyway, I pulled myself together to teach Ukrainian classes on Tuesdays in Newport and Thursdays in Westport. I do the laundry on Mondays in between clearing out the stuff at Ross House with Kirstin, do the food shopping on Wednesdays, and take Fridays off. </p><p>I must say, my Ukrainian has improved in these past few months to point of fluency again. It helps as I am teaching real beginners. My students in Westport are making progress. They are at least trying to speak. When I started, a few refused to say anything. But with a little cajoling, they have started being brave. That's my class above. We had a lesson about Christmas in Ireland at the last session. They couldn't believe that the Irish don't celebrate Christmas Eve. They gave me a lovely Christmas present and wrote a poem - in English. They made me cry!</p><p>My class in Newport is fluid with new arrivals weekly. I am now helping a family who have a young son with cerebral palsy. I also placed a family of seven in a beautiful home in Fahy in the middle of nowhere. But they bought a car and are very self-sufficient. I've been sharing insights with the volunteers instructors in Newport, which is helping them. Things like dogs don't say bow-wow in Ukrainian so one of the lessons they had in mind wouldn't work. Also, Ukrainian traditions like St Nicholas brings gifts on the 19th of November, so the principal in Newport gave all the Ukrainian kids little gifts for St Nick's. </p><p>We had our first dinner party, aside from having had family over (Chris, Marika, Aileen and Sheila) when they were here in November. We served lamb from Inishdaff on both occasions. It was actually great fun entertaining again. Clearly, I am feeling better. </p><p>The week before Christmas, I got what I thought was a common cold, but it turned out to be a bit more. I tested negative for Covid but the symptoms indicated RSV (respiratory syncytial virus). Runny nose, low-grade fever, sneezing, wheezing and croupy cough. It's been going around. Everyone in our neighbourhood has had it. So for Christmas, I gave it to Alex. Happy Christmas, honey! We didn't do Christmas eve as we were both too miserable. But I was able to marinate the beets for Uki Christmas and managed to make chocolate chip cookies. And I recovered enough to make the Christmas dinner, with turkey, mashed potatoes, gravy, stuffing, cranberry sauce and carrots. Ho ho ho!</p><p>For Stephen's Day, we hung around and then had a lobster dinner -- one of Alex's Clew Bay lobsters frozen this summer. Yum. And I baked a plyatsok, so it felt a bit festive. </p><p>It's been raining on and off so it is not tempting to be outside. At least it's a bit warmer than it was a couple of weeks ago when we suffered an arctic blast. I am ready for 2023, as 2022 was rather a bust. </p><p><br /></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjs_N0L0ZPmbu2xlCIipK2oLnMQZKuwHavcIyOXMHf7hVOB8YsuD2axXJwaXOrwpF9cmaCc1XeFGobkNZnCApQ1EAWNrP_j04eRbLJHLRLUezfYe8xQg_F0B4jZjf0nV5o5Ib3fCmD0yPnKQS-lLgAtd05KsC9BBe__uwTL6QzTuai39nfWxlqz2LG4/s4624/20221223_182519.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="4624" data-original-width="3468" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjs_N0L0ZPmbu2xlCIipK2oLnMQZKuwHavcIyOXMHf7hVOB8YsuD2axXJwaXOrwpF9cmaCc1XeFGobkNZnCApQ1EAWNrP_j04eRbLJHLRLUezfYe8xQg_F0B4jZjf0nV5o5Ib3fCmD0yPnKQS-lLgAtd05KsC9BBe__uwTL6QzTuai39nfWxlqz2LG4/s320/20221223_182519.jpg" width="240" /></a></div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgSA1q5Y3GDW9JBTmo-i8u2vWq6Gcz6VIFxaMMK1QNLKp3PBCKQn6Et6TQVPFA3vEmWDaIKe8MZUDXZDLnLi5YU1gmiipnPu6fNj-MIqenjPfmjW72XjOX3GNXjhm_t_jEXRXe30I1CxYW2YZnc1XrQjXZ4VOVN-f0kGz0fd0hX-PH62DOJhUoAvTwg/s4624/20221223_182526.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="4624" data-original-width="3468" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgSA1q5Y3GDW9JBTmo-i8u2vWq6Gcz6VIFxaMMK1QNLKp3PBCKQn6Et6TQVPFA3vEmWDaIKe8MZUDXZDLnLi5YU1gmiipnPu6fNj-MIqenjPfmjW72XjOX3GNXjhm_t_jEXRXe30I1CxYW2YZnc1XrQjXZ4VOVN-f0kGz0fd0hX-PH62DOJhUoAvTwg/s320/20221223_182526.jpg" width="240" /></a></div><br /><p><br /></p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-49073622689497082672022-10-17T16:06:00.002+01:002022-12-27T13:08:30.315+00:00That sinking feeling<h2 style="text-align: left;"><b>That sinking feeling</b></h2><p>by Daria Blackwell</p><p><br /></p><p>I feel the knots in my core. </p><p>Twisting. Erupting. Gnawing.</p><p>My head throbs and my eyes bulge,</p><p>I am like a wild animal caught in a trap.</p><p>I hate being here. I want to run and hide.</p><p>I want the peace and solace of home.</p><p>I can’t deal with people all the time. </p><p>I must be on my own to recharge</p><p>And that can’t be just on a different boat. </p><p>Or on another note in time. </p><p>It has to be out of sight to be out of mind. </p><p>Being trapped causes my mind to spiral</p><p>Deep into abysses I can usually avoid.</p><p>I want to shed all responsibility and flee.</p><p>But I am enveloped by a sea of lost tranquility.</p><p>I want to cry. I want to slip overboard.</p><p>I want to cut the lines loose and drift out to sea. </p><p>Where if the sinking feeling is real,</p><p>I won’t have to deal with it anymore. </p><p><br /></p><p>Written aboard <i>Aleria </i>on June 28, 2022, a day before my 68th birthday.</p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-19395660774572662442022-09-07T18:23:00.001+01:002022-09-07T18:23:21.921+01:00Lost in space<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiAolf3vWZrJjFazewfo_WHYsAyHXy-OHCJ1ok-x12YkhFq17z8QY5bCBBHgz3Vxl_MvLdtIBk2p5S2_ZGXrLxN9Z6xYW03QunEzq-AQJZU_I88tNLSWmh6NTM3TpvxCcrh89y6X_-6TJf6vuOkekMRxplR9Ul6p9arXbWEEfYIhybmVB-wswFdHUDK/s3456/20220824_131928.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="3456" data-original-width="3456" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiAolf3vWZrJjFazewfo_WHYsAyHXy-OHCJ1ok-x12YkhFq17z8QY5bCBBHgz3Vxl_MvLdtIBk2p5S2_ZGXrLxN9Z6xYW03QunEzq-AQJZU_I88tNLSWmh6NTM3TpvxCcrh89y6X_-6TJf6vuOkekMRxplR9Ul6p9arXbWEEfYIhybmVB-wswFdHUDK/s320/20220824_131928.jpg" width="320" /></a></div><p><br /></p><p>I don't know what's wrong with me, but I know there is something. I have that sinking feeling again. Perhaps a bit of PTSD? I can't write. I don't want to travel, yet I feel like I'm missing out. I don't want to be with people. I don't want any responsibilities. I want to resign from all my volunteer activities. I am anxious all the time, and yet I have no interest in anything. </p><p>I've lost my mojo. I've lost my confidence. I have no passion. I've lost some of my soul. In fact, I am afraid. </p><p>I have nightmares. I am going to physio because my shoulders and neck are tied up in knots. I shouldn't be having this anxiety. I am fully vaccinated with two boosters, each of a different vaccine. I've survived Covid itself without much ado. So I shouldn't be worried about that. </p><p>I definitely think I am an ugly old woman when I look in the mirror. I remember my mom saying the same thing around this age, although I am more mobile and active than she was. </p><p>I don't know how to find what I want to do next. Maybe it should be just escaping into the books that I've bought for that purpose but haven't been willing to tackle? Maybe I should take that winemaking course in Burgundy or at least online. </p><p>I feel like I'm running out of time, but then I wonder what's the point. If I see everything on earth, will it help me in eternity, if that exists? </p><p>I know I should be grateful for everything I have: a wonderful husband, a wonderful home in a beautiful place, my health. So many in the world are suffering. Floods in Pakistan, famine in Somalia, fires in California and France and elsewhere, war in Ukraine. And then there's Trump and Liz Truss. </p><p>Why can't I just be happy, or at least content? Why am I so sad? Maybe because of the state of the world? It all seems so pointless. </p><p><br /></p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-5886224316892581642022-07-24T12:55:00.000+01:002022-07-24T12:55:04.508+01:00Farewell to Meike <p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhtMXSMomazAuY3Rqgf7jC-dTYvGuaTCFuZyuUP_lI29rzd-HKpgMmGBlaR9BD9TRqxuJT-U8I1Zo-3LZ_jwyPB1xG-a4NqojwtOAXOq8Y6OfvgE_xZDKNfvMcAjF3LY1dtO9L1lJK76irrWBlHYqslokRkUSHy2MH0bYS1VrKAJFvyNAmKrLPtV0Or/s1626/Card%20back.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1098" data-original-width="1626" height="216" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhtMXSMomazAuY3Rqgf7jC-dTYvGuaTCFuZyuUP_lI29rzd-HKpgMmGBlaR9BD9TRqxuJT-U8I1Zo-3LZ_jwyPB1xG-a4NqojwtOAXOq8Y6OfvgE_xZDKNfvMcAjF3LY1dtO9L1lJK76irrWBlHYqslokRkUSHy2MH0bYS1VrKAJFvyNAmKrLPtV0Or/s320/Card%20back.jpg" width="320" /></a></div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEip9YptU_svFKtrpfp8LiNNwLA8jG1CRZM8pimK1bT6zt7sztMns4TRm20qljn6cn4l3fNib9yczDuHF0wCSYOpMCTr_BPHrfc9RJusuGLH43KLd1N17oP_FGIhqEXT0cQFl6HMWIpHa0V4bGOsTWFVqzjCJzaXHaTFs0oO3xnAb3RwqtJ2_3Z6D2TI/s1641/Card%20front.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1104" data-original-width="1641" height="215" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEip9YptU_svFKtrpfp8LiNNwLA8jG1CRZM8pimK1bT6zt7sztMns4TRm20qljn6cn4l3fNib9yczDuHF0wCSYOpMCTr_BPHrfc9RJusuGLH43KLd1N17oP_FGIhqEXT0cQFl6HMWIpHa0V4bGOsTWFVqzjCJzaXHaTFs0oO3xnAb3RwqtJ2_3Z6D2TI/s320/Card%20front.jpg" width="320" /></a></div><br /> <p></p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-39021582717055777332022-05-16T11:29:00.002+01:002022-10-17T16:07:24.612+01:00Cars I have owned<p>My first car was a Pontiac LeMans (dirty gold) 350 HP V8 muscle car which my sister gave me when she went to Brazil. I hated it but it was all American powerful. When I had to park in garages, they'd always ask what color it was. It was a dirty gold or dark mustard color. Ugly. I sold it during the fuel crisis when the cost of gasoline went through the roof and we had huge backups at the pump where we could only fuel up on alternate days. I did not buy this car, but I traded it for a fuel-efficient Honda Accord. </p><p><br /></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgDMnAFRyvgVCTxfGgdEzcEZXcugeXLGiFAzYtfT1D5m5QeQGawCyHCEiivgbHJWXgygXyFvbGqZuIQCeJIZ1kSpIe1nERhu7NZ8UPkZ3dnEFEKI0bTA3acGnGdeb4An4CA_ie1FtLY0bnTtkwmvjfmollLO-vnGM9piYlB7wEFa2kVFT5-43V6m4QY/s1920/1970-pontiac-lemans-sport.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1281" data-original-width="1920" height="214" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgDMnAFRyvgVCTxfGgdEzcEZXcugeXLGiFAzYtfT1D5m5QeQGawCyHCEiivgbHJWXgygXyFvbGqZuIQCeJIZ1kSpIe1nERhu7NZ8UPkZ3dnEFEKI0bTA3acGnGdeb4An4CA_ie1FtLY0bnTtkwmvjfmollLO-vnGM9piYlB7wEFa2kVFT5-43V6m4QY/s320/1970-pontiac-lemans-sport.jpg" width="320" /></a></div><b>Cars I bought</b><span style="font-size: medium;">:</span><p></p><p>Honda Accord (gold) - hatchback -- wrecked </p><p>Honda Accord (silver) - sedan -- good performer</p><p>Triumph TR7 (green) -- piece of junk</p><p>Nissan 300ZX (red) -- hot stuff</p><p>Nissan Altima (black) -- 4-door sports car</p><p>Lexus LS400 (gold) Sammy (Samurai) -- old man's car</p><p>Mercedes SLK320 (burgundy) Maxie (Maximilian) -- fabulous car</p><p>Mini One (black) Mickey (Micky Mouse) -- fun car (Sold)</p><p>Ford Focus (gunmetal grey) Finn (Finn McCool) -- great to drive</p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh-HQrO6dd0U5dsBp7GSulJiOQyx9TBOu8P9zQl6TZTJGmaphDVvlk12UhCIjOtIyJYhPS8LsX9KfyIOX0AjF1VEzlArF7G6iXpBnFtOEZjFWV4fvXTvF7t2E7YsvBzo2pYreeORKvJY18qPHLCf82vWq04XsC1U08_1fLzEBwUaeknrbtL__gg0Uk4/s4624/20220511_142108.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="3468" data-original-width="4624" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh-HQrO6dd0U5dsBp7GSulJiOQyx9TBOu8P9zQl6TZTJGmaphDVvlk12UhCIjOtIyJYhPS8LsX9KfyIOX0AjF1VEzlArF7G6iXpBnFtOEZjFWV4fvXTvF7t2E7YsvBzo2pYreeORKvJY18qPHLCf82vWq04XsC1U08_1fLzEBwUaeknrbtL__gg0Uk4/s320/20220511_142108.jpg" width="320" /></a></div><p><br /></p><p>What I have always wanted but will never have is a Jaguar XKE. </p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjIMMJ4NWpdz9rlcbpvuXjwsjLCD82SKQJJz8K0-iiESggDj00O6XR_bzO9viVXQmD3DRtw1tW1yM44Y-_YE5fsXz-vExjCrqW4BuI4JRsOxOqMOYih1wIr3YaAOBobPtRF1Lx2hMyfDe2K_Ruy-m0DfUlJqv_TZkJBQyLS8vuyE9bBBeFmTYCmtkPR/s962/Screenshot%20(136).png" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="560" data-original-width="962" height="186" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjIMMJ4NWpdz9rlcbpvuXjwsjLCD82SKQJJz8K0-iiESggDj00O6XR_bzO9viVXQmD3DRtw1tW1yM44Y-_YE5fsXz-vExjCrqW4BuI4JRsOxOqMOYih1wIr3YaAOBobPtRF1Lx2hMyfDe2K_Ruy-m0DfUlJqv_TZkJBQyLS8vuyE9bBBeFmTYCmtkPR/s320/Screenshot%20(136).png" width="320" /></a></div><br /><p><br /></p><p><br /></p><p><br /></p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-66713834924813049582022-05-13T10:52:00.001+01:002022-05-16T11:30:56.130+01:00The US records surpass 1 million deaths due to Covid<p><br /></p><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXuKnvIzVj8LwG-2ptbqXGnB6ArFwdvAEBdLUbqb76o6aRQo3JVDv2ul9v3jO2GekMUR2bP7f670083lJzT88WyEOEEAlXAtAfyrrjloiCIVsCQAAAl5e0N05B-3Ekx9Quiy1D86F02K3nfqqNlIfh4-J9LAAd4e-WB3qE75iYRL6IEQy_JaKzLWOQ/s1920/San_Francisco_from_the_Marin_Headlands_in_March_2019.jpg" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="1125" data-original-width="1920" height="235" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXuKnvIzVj8LwG-2ptbqXGnB6ArFwdvAEBdLUbqb76o6aRQo3JVDv2ul9v3jO2GekMUR2bP7f670083lJzT88WyEOEEAlXAtAfyrrjloiCIVsCQAAAl5e0N05B-3Ekx9Quiy1D86F02K3nfqqNlIfh4-J9LAAd4e-WB3qE75iYRL6IEQy_JaKzLWOQ/w400-h235/San_Francisco_from_the_Marin_Headlands_in_March_2019.jpg" width="400" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">San Francisco 2019 </td></tr></tbody></table><p><br /></p><p>It is hard to fathom that more than <a href="https://www.reuters.com/world/us/covid-claims-1-million-us-lives-leaving-trail-loss-2022-05-11/?utm_source=Sailthru&utm_medium=newsletter&utm_campaign=daily-briefing" target="_blank">1 million people</a> in the United States alone are confirmed to have died due to Covid, more than the population of San Francisco. Globally, the figure of confirmed victims is 6.7 million but the WHO estimates more like 15 million. </p><p>The last couple of months has been pretty wild for Alex and me and our families. On 24 February, when Russia invaded Ukraine, I started helping settle Ukrainian families in Ireland. Ireland opened its doors to Ukrainians without visas or connections here and more than 30,000 have now arrived. The communities in Newport, Westport and Rosmoney got behind the effort and people offered their homes, clothing, food and moral support. I was, and am, very grateful to the Irish for their kindness and generosity. </p><p>Then Alex's mom, Meike, who had just moved to Kirstin's house a month before, had a second stroke -- a massive one from which she did not recover. But she lingered fighting for a week. It was awful to see her spirit slowly depart from the body. We had a funeral service in the Protestant Church with a packed crowd, followed by a Cremation in Cavan. That night we all stayed at Miriam's house in Monaghan and spent the night telling stories about Meike. She will be sorely missed. </p><p>Alex and I then made the decision to stick with our planned US trip for the first week of April. We had the OCC AGM and Awards weekend in Annapolis to take part in, and then we were to visit Alexis and Andrew. We hadn't seen their family in 3 years and Alex had never met baby Miles. We looked forward to that immensely. I also had to renew my driving license, and we had bank accounts to straighten out, so it was rather an important mission. We bit the bullet and made the trip. I left my car to the Kisorets family out in Rosmoney while we were gone, but I figured they would end up keeping it longer term, and they have. </p><p>I'll spare you the details, but suffice it to say that travel has taken on a new dimension post-Covid. It was a really enjoyable trip. The day we got home, we started experiencing clear symptoms of Covid. Fever and chills alternating with sweats, cough, etc. Two days later, we tested very positive by lateral flow test. Exactly ten days later was Meike's burial on the island. Alex had organised Peter's boat to take all who wanted to come over to Inishdaff. Fortunately, Alex tested negative though he still had symptoms -- cough, shortness of breath and exhaustion. I still tested positive for 2 more days. Masked and distanced, I attended both the service and the reception at Ross House afterwards which was crammed with people. I have not heard of any cases as a result, so I remain hopeful that I was no longer infectious.</p><p>I continue helping my Ukrainians. We had lunch with about 40 of them in Newport the day of the re-enactment of Newport 300. It was amazing to finally meet Anna and Julia and so many others who all wanted to talk to me. </p><p>It's been a whirlwind. This week, Alex and I went to look at cars. I wanted electric (originally the Tesla) and we tested and liked the Hyundai Kona, but it won't be available until July at the earliest and the cost of electricity has skyrocketed. I was worried about buying that at this time. And I can't take Mickey away from the Kisorets. It has changed their lives. </p><p>Then we stopped in at Cosgraves in Castlebar and looked at two sedans, a Mercedes and a BMW. Both were nice but not 'right'. But at Cosgraves in Westport we spotted a 2019 Ford Focus. We liked the test drive and I bought it on the spot. €22K. I have never done anything so radical in my life. It felt weird, I second-guessed, but I think I made the right decision. Between Brexit and the war in Ukraine, buying good cars has become a challenge. New ones are not available because the chips are made in Ukraine. Used cars are not available because Brexit has made import difficult. I was concerned this one would not last, it was that clean with 34K miles. We can always trade it in when EVs become more widely available.</p><p>Meet Finn McCool...Ford Focus Finn. The first American car (built in Germany for the UK market with right-hand drive) I have ever bought. And Finn has Dublin plates...pshaw!</p><p><br /></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhiyRXsYsZb2oS2HM8T1h5vh5IHrYhUaOA-ZsDqXwGC-zs9bChpb-bU_05ioBnvdn884XWGsKtghGInoSTcB-EAsheWnv1NXw5yqT4-R2gbBtkwsJI64KGy-bQ0SLfMNoKrI9BJ7gHZVDq1asqH6kmoY_NHEFPhz3mTbPSfO8FEh8-4hkqBSrCMoL50/s4624/20220511_142125.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="3468" data-original-width="4624" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhiyRXsYsZb2oS2HM8T1h5vh5IHrYhUaOA-ZsDqXwGC-zs9bChpb-bU_05ioBnvdn884XWGsKtghGInoSTcB-EAsheWnv1NXw5yqT4-R2gbBtkwsJI64KGy-bQ0SLfMNoKrI9BJ7gHZVDq1asqH6kmoY_NHEFPhz3mTbPSfO8FEh8-4hkqBSrCMoL50/s320/20220511_142125.jpg" width="320" /></a></div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgetMAMZpfB0S0vgkYeQBQXjnOqOzzuwe914P2KwDfwvgrojow6TAFfBD2xVP5fHa3Dc29o6XqJ3uTQLBaX6FqV_R33GQhPTRt5VpN3qmEbTJnFRUobW4sGVulVfXmivRdqWebav1Vgm5hkUm-jBycDW1tx4KOiarGaR9ra1BmvPzm-jpKHMUhVekwm/s4624/20220511_142108.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="3468" data-original-width="4624" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgetMAMZpfB0S0vgkYeQBQXjnOqOzzuwe914P2KwDfwvgrojow6TAFfBD2xVP5fHa3Dc29o6XqJ3uTQLBaX6FqV_R33GQhPTRt5VpN3qmEbTJnFRUobW4sGVulVfXmivRdqWebav1Vgm5hkUm-jBycDW1tx4KOiarGaR9ra1BmvPzm-jpKHMUhVekwm/s320/20220511_142108.jpg" width="320" /></a></div><br /> <p></p><p><a href="https://www.nytimes.com/interactive/2022/05/13/us/covid-deaths-us-one-million.html?campaign_id=2&emc=edit_th_20220515&instance_id=61424&nl=todaysheadlines&regi_id=21860213&segment_id=92318&user_id=b9a8dfbb204099e98df802eb0186aa4d" target="_blank">How America Lost One Million People</a> NYT 15 May 2022</p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-16739788567346620652022-02-09T11:55:00.002+00:002022-02-09T11:55:14.156+00:00More than 400M confirmed cases<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/a/AVvXsEgYBeaVZEOK-Lue6G_ZLN-2S9ILEqoAq42p0TA7KntoEPgJIJbtTcB_x-nYGnh9D_ISvTIIJY61Y6tjjzgrk_evYvARHgLOwLd7bkslHwUt8b9YxNcmTS6yTp7gFYZN6hM7MGViuG3ikdZ_QJwIoiKu_hTn5pXhlXilRTcTlF22aS6thnpa3xjKQHNT=s1200" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="868" data-original-width="1200" height="231" src="https://blogger.googleusercontent.com/img/a/AVvXsEgYBeaVZEOK-Lue6G_ZLN-2S9ILEqoAq42p0TA7KntoEPgJIJbtTcB_x-nYGnh9D_ISvTIIJY61Y6tjjzgrk_evYvARHgLOwLd7bkslHwUt8b9YxNcmTS6yTp7gFYZN6hM7MGViuG3ikdZ_QJwIoiKu_hTn5pXhlXilRTcTlF22aS6thnpa3xjKQHNT=s320" width="320" /></a></div><p><br /></p><p>The US has surpassed 900k deaths, while the world has recorded 5.8M deaths. Even though Omicron is less severe, its transmissibility means so many more are infected at any one time that the daily number of hospitalisations and deaths is much higher than in any previous wave. The majority of those dying are <a href="https://www.washingtonpost.com/health/2022/02/08/omicron-deaths-covid/" target="_blank">over 75 years of age and the unvaccinated</a> or medically vulnerable. Even mild cases are showing substantial <a href="https://www.medscape.com/viewarticle/968105" target="_blank">CVD risk</a>. There's a new link to <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788641" target="_blank">Type I diabetes</a> and other chronic conditions, so the long-term consequences of infection will continue to burden the HC system. I am back to double masking. </p><p>We have made reservations to travel to the US in April. I am not looking forward to it at all. </p><p>The Pew Research Center did a <a href="https://www.pewresearch.org/fact-tank/2021/12/17/striking-findings-from-2021/" target="_blank">summary</a> of 2021 in the US and it was not hopeful or joyful. It was bleak. </p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-13333202490089513052022-01-28T13:32:00.005+00:002022-01-28T13:32:42.057+00:00Tsunami not wave<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/a/AVvXsEg3oZKDqHEy7xNNSK1GIMvVYAd2T_Q_NbF8tGGvGJCNNJDcDMtXYCHi-SR_pWMTgIEFyOoewJf3EYno3x9MnQEhHwqfKwGFVPw9LjZVkWXMu1y4FFv6qh4y6iOrNeUl8WdomoimBQwP5ziOXFe3-U5aazK6wMZppO4jLRWpqbKMT85EY5WbV-_kKpUk=s2420" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="2420" data-original-width="1200" height="400" src="https://blogger.googleusercontent.com/img/a/AVvXsEg3oZKDqHEy7xNNSK1GIMvVYAd2T_Q_NbF8tGGvGJCNNJDcDMtXYCHi-SR_pWMTgIEFyOoewJf3EYno3x9MnQEhHwqfKwGFVPw9LjZVkWXMu1y4FFv6qh4y6iOrNeUl8WdomoimBQwP5ziOXFe3-U5aazK6wMZppO4jLRWpqbKMT85EY5WbV-_kKpUk=w199-h400" width="199" /></a></div><p><br /></p><p>The fourth wave turned out to be a tsunami not a wave, taking the world by tidal waves. Omicron being more infectious but less deadly is doing what I had hoped -- infecting enough people quickly enough without overwhelming the health care system to spread widely without allowing new variants to emerge. Although it's scary to see the numbers, it's incredibly hopeful to see the restrictions easing even though we still have a long way go on the way down. </p><p>As the world rapidly approaches 400M confirmed cases and 6M dead, the reality is that the truth is probably way ahead of these figures. And we still have billions to go. </p><div id="maincounter-wrap" style="background-color: white; box-sizing: border-box; color: #222222; font-family: "noto sans", sans-serif; font-size: 15px; margin: 15px auto auto; padding-top: 20px; text-align: center;"><h1 style="box-sizing: border-box; color: #555555; font-family: "roboto condensed", sans-serif; font-size: 40px; font-weight: 300; line-height: 1.3; margin: 0px;">Coronavirus Cases:</h1><div class="maincounter-number" style="box-sizing: border-box; color: dimgrey; font-size: 54px; font-weight: 700;"><span style="box-sizing: border-box; color: #aaaaaa;">367,423,717</span></div></div><div style="background-color: white; box-sizing: border-box; color: #222222; font-family: "noto sans", sans-serif; font-size: 15px; text-align: center;"><a href="https://www.worldometers.info/coronavirus/#countries" style="background-color: transparent; box-sizing: border-box; color: #699a21;">view by country</a></div><div id="maincounter-wrap" style="background-color: white; box-sizing: border-box; color: #222222; font-family: "noto sans", sans-serif; font-size: 15px; margin: 15px auto auto; padding-top: 20px; text-align: center;"><h1 style="box-sizing: border-box; color: #555555; font-family: "roboto condensed", sans-serif; font-size: 40px; font-weight: 300; line-height: 1.3; margin: 0px;">Deaths:</h1><div class="maincounter-number" style="box-sizing: border-box; color: dimgrey; font-size: 54px; font-weight: 700;"><span style="box-sizing: border-box;">5,658,763</span></div></div><div id="maincounter-wrap" style="background-color: white; box-sizing: border-box; color: #222222; font-family: "noto sans", sans-serif; font-size: 15px; margin: 15px auto auto; padding-top: 20px; text-align: center;"><h1 style="box-sizing: border-box; color: #555555; font-family: "roboto condensed", sans-serif; font-size: 40px; font-weight: 300; line-height: 1.3; margin: 0px;">Recovered:</h1><div class="maincounter-number" style="box-sizing: border-box; color: #8aca2b; font-size: 54px; font-weight: 700;"><span style="box-sizing: border-box;">290,556,684</span></div></div>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-35314180894211467392022-01-09T18:32:00.004+00:002022-01-09T18:36:35.226+00:00Pandemic resurgence<p></p><div class="separator" style="clear: both; text-align: center;"><br /></div><br /><br /><p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/a/AVvXsEho6BzaHPpPU0EHcXIOFty2lTIRCeYccFzWGGdXPrU2Z1sRuLAjpgvVMpJ98efdja7ITY-z_6NQDQA57qBpM8lj0aMFGoe2AmrdKLY_Us5e93GVgqD7PgvJty2DmmwsWyCvJmPCxTV1ndbkFW14_KzrJvVedYK2iDsxrZaTNoa7Ga3FV_saiN4NmprN=s1053" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="423" data-original-width="1053" height="161" src="https://blogger.googleusercontent.com/img/a/AVvXsEho6BzaHPpPU0EHcXIOFty2lTIRCeYccFzWGGdXPrU2Z1sRuLAjpgvVMpJ98efdja7ITY-z_6NQDQA57qBpM8lj0aMFGoe2AmrdKLY_Us5e93GVgqD7PgvJty2DmmwsWyCvJmPCxTV1ndbkFW14_KzrJvVedYK2iDsxrZaTNoa7Ga3FV_saiN4NmprN=w400-h161" width="400" /></a></div><br /><p>The world has surpassed 305M confirmed coronavirus cases and 5.5M confirmed deaths, although the <a href="https://www.nbcnews.com/science/science-news/covid-death-toll-india-likely-far-higher-official-record-research-says-rcna11357" target="_blank">death total is likely much greater</a>. But it has become quite clear, that the surge in cases caused by the Omicron variant is different from the Delta wave and other previous waves. It is like a tsunami of Covid-19 cases, but the hospitalisations and deaths remain relatively low. Yet, if cases are three-fold higher, then the absolute number of hospitalizations and deaths will still overwhelm the healthcare systems. The majority of the people hospitalised and dying are unvaccinated. We've had the two-dose series plus a booster -- Astra Zeneca (viral vector vaccine) followed by Pfizer/BioNtech (mRNA vaccine). </p><p>Even more astonishing is that <a href="https://coronavirus.jhu.edu/map.html" target="_blank">9,405,751,450</a> doses of vaccines have been administered worldwide as of Jan 9 with almost a billion delivered in the last 28 days. So with 300,000,000 recovered and more than 9 billion vaccine doses administered (so about 4.5 billion people vaccinated), that would suggest that more than half the world population of 7.9 billion has some degree of immunity. We are not at herd yet, but we may be getting there rapidly. </p><p>It is thought that because Omicron is much milder and more highly transmissible, the actual rate of infection is much higher than diagnosed. PCR tests and even antigen tests have been hard to come by in the last few weeks as Omicron surged and holiday revelry gave it its ticket to ride. The indications from GB and SA are that the Omicron wave has crested there and the transmission rate is slowing. I expect us to hit peak this week. Almost everyone we know has had it or been a close contact of someone who has. </p><p>My greatest hope is that Omicron will create a stable environment where we can coexist with Covid. As long as Omicron can infect enough people to suppress the development of new variants that are more severe, we will enter a new relationship with this virus in which we share the world and accept the degree of risk, just as we do with the flu. </p><p>I have not been writing much, but perhaps now I can begin anew. I polished our silver for the first time in two years today. It felt cathartic to wipe away two years of tarnish. For your information, I worked with vaccines in the biologicals industry for most of my career and helped launch the first rDNA vaccine (for hepatitis B) and many others. I used to think vaccines were my life. Now I know they are. </p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-51209517728336828222021-11-04T18:51:00.000+00:002021-11-04T18:51:31.165+00:00The fourth wave<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiCsP10hOHu55F-qdBzMWKMZVCGslzH4CGf_f9Z3iyQsNcusNkrvwW4d0ZCSgOeMeNWrYi7JuQ_w5QzQixIURDTytnfjjiPGZExLikIvc6EP6mSHNGAb8K8Kn629HKNkNM7a65dWCpYcFo/s2048/20211104_112745.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1536" data-original-width="2048" height="300" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiCsP10hOHu55F-qdBzMWKMZVCGslzH4CGf_f9Z3iyQsNcusNkrvwW4d0ZCSgOeMeNWrYi7JuQ_w5QzQixIURDTytnfjjiPGZExLikIvc6EP6mSHNGAb8K8Kn629HKNkNM7a65dWCpYcFo/w400-h300/20211104_112745.jpg" width="400" /></a></div><p><br /></p><p>As the world approaches 250MM confirmed cases of Covid-19 and surpasses 5 million confirmed dead, a new wave of coronavirus hits Europe. The COP 26 conference in Scotland is hosting more than 30,000 delegates to the convention on climate change, and it will probably precipitate another global outbreak. An article in the Guardian predicts 500,000 more deaths by January.</p><p>The Mu variant, first identified in Colombia, has now been shown in a paper in the NEJM to be 1.5 times more resistant to vaccine-induced antibody neutralization and 2.0 times more resistant to convalescent serum. This is worrying. We are scheduled to receive booster doses of vaccine, but that won't happen until 6 months post-vaccination; mine was June 23 so I have to wait until Christmas. </p><p>Meanwhile, our sweet kitty Cinquo has squamous cell carcinoma in his jaw. Today he couldn't eat much anymore. He just cannot chew. He cannot clean himself and he has been stumbling. Today, he kept coming to my office and asking me to help him. This is his last day before crossing that rainbow bridge. That's probably why I saw so many rainbows while out walking today. My little loverboy will be no more. RIP Cinquo. The gentlest cat I ever knew. I will miss you sorely. </p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh8ZuNWlc9vee4ipp3P5-mXxp9teg3y5B4DkxgKG_jB0kGPqnn4Na0mSwTYQEILyxOcyUi2WEDGh_JyuErTUZheu3oOy-ATkdwzX3NZDgxjPdX8swfynrNTrVmJioAuD3OtIt-gDyBtJwU/s2048/20140528_123810.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1536" data-original-width="2048" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh8ZuNWlc9vee4ipp3P5-mXxp9teg3y5B4DkxgKG_jB0kGPqnn4Na0mSwTYQEILyxOcyUi2WEDGh_JyuErTUZheu3oOy-ATkdwzX3NZDgxjPdX8swfynrNTrVmJioAuD3OtIt-gDyBtJwU/s320/20140528_123810.jpg" width="320" /></a></div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgWr1iHc2vb0NzvrfjlW4kzPKr2Pl2pabntRWzGk8Tk4-d7DCX0KBpli_CVY3I_dOfx1q6wToo8hSdln_1jjvo8Qhkf-oCYVKfQmU_e29Km-S0pcyU7B1iMPaQUIk2YMRKPjOrNu42afe8/s2048/20200506_094600.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="2048" data-original-width="1536" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgWr1iHc2vb0NzvrfjlW4kzPKr2Pl2pabntRWzGk8Tk4-d7DCX0KBpli_CVY3I_dOfx1q6wToo8hSdln_1jjvo8Qhkf-oCYVKfQmU_e29Km-S0pcyU7B1iMPaQUIk2YMRKPjOrNu42afe8/s320/20200506_094600.jpg" width="240" /></a></div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhWMdfTxoVobmzr4xWKjV2xwJ4Up4JywZ4VA0vS5w_Nrb-w-M462wW35CnfADKb1S32CHSnvxqfiRYFcOtWO3_7e3ICUAzeEw_O1IjsqzFcaHN4z0Ij73G2T9LmNjDxP3sDZc7SJ9jdjuY/s2048/20190519_210553.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="2048" data-original-width="1536" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhWMdfTxoVobmzr4xWKjV2xwJ4Up4JywZ4VA0vS5w_Nrb-w-M462wW35CnfADKb1S32CHSnvxqfiRYFcOtWO3_7e3ICUAzeEw_O1IjsqzFcaHN4z0Ij73G2T9LmNjDxP3sDZc7SJ9jdjuY/s320/20190519_210553.jpg" width="240" /></a></div><br /><p><br /></p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-53101672878957410212021-10-18T09:17:00.024+01:002022-09-04T19:24:09.474+01:00Vaccines against SARS-CoV-2<p style="text-align: center;"> <a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhy3Su1NYgHEPOHQpXrAKUVxzeBrnAyTnYj1b17Ec9NMvjeqU6d0UXHTHAKBRzPNSiW4ARgAPY7Pm1rI_cAnGBiFBh2tcv5jOnabncM3F67Lc6zJjzz61mHNo2q3MO_siPPoJ6uuqlSegM/s625/cg5fd6f47b9cd8f.jpg" style="margin-left: 1em; margin-right: 1em; text-align: center;"><img border="0" data-original-height="420" data-original-width="625" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhy3Su1NYgHEPOHQpXrAKUVxzeBrnAyTnYj1b17Ec9NMvjeqU6d0UXHTHAKBRzPNSiW4ARgAPY7Pm1rI_cAnGBiFBh2tcv5jOnabncM3F67Lc6zJjzz61mHNo2q3MO_siPPoJ6uuqlSegM/s320/cg5fd6f47b9cd8f.jpg" width="320" /></a></p>I am compiling basic information about the Covid-19 vaccines here as it is published. I am reporting both peer-reviewed publications and press release information because this is the era of clinical trial reporting by PR channels. I do not certify the accuracy of anything on this page. I will be updating it as information is released primarily for myself.<div><br /></div><div><span style="font-size: large;">Vaccines<br /><br /></span><a href="https://tmsnrt.rs/3c7R3Bl" target="_blank">Reuters Vaccine Tracker</a><br /><p></p><table border="0" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-collapse: collapse; mso-padding-alt: 0cm 0cm 0cm 0cm; mso-yfti-tbllook: 1184; width: 617px;">
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<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Developer/country</span></b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><o:p></o:p></span></p>
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<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Vaccine
type</span></b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><o:p></o:p></span></p>
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<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Seroconversion
Rate</span></b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><o:p></o:p></span></p>
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<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Protective
Efficacy</span></b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><o:p></o:p></span></p>
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<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Status</span></b><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><o:p></o:p></span></p>
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<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Pfizer/BioNTech
– US/Germany<br />
'<a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">Comirnaty</span></a>'<o:p></o:p></span></p>
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<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">mRNA
spike LNP<o:p></o:p></span></p>
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<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">95.2%</span></a> CD4+ T cell <o:p></o:p></span></p>
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<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">95%</span></a> after 2 doses<br />Effective against <a href="https://www.thejournal.ie/pfizer-vaccine-covid-variants-5337678-Jan2021/" target="_blank">variants</a><o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.nejm.org/doi/full/10.1056/NEJMc2104974?query=TOC" target="_blank">75%+ against variants and 97% against severe inf</a></p>
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<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Full <a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">FDA Approval Dec 10</span></a>, 2021<br />
<a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">EU Dec 21</span></a><o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.nytimes.com/2021/05/10/health/pfizer-vaccine-children-kids.html?campaign_id=2&emc=edit_th_20210511&instance_id=30565&nl=todaysheadlines&regi_id=21860213&segment_id=57726&user_id=b9a8dfbb204099e98df802eb0186aa4d" target="_blank">Children 12-15 US</a></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.precisionvaccinations.com/2021/07/10/biontech-and-pfizer-provide-vaccine-booster-update?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Booster recommended</a></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.reuters.com/business/healthcare-pharmaceuticals/uk-study-finds-mrna-covid-19-vaccines-provide-biggest-booster-impact-2021-12-02/?utm_source=Sailthru&utm_medium=email&utm_term=The%20Reuters%20Daily%20Briefing&utm_content=3-12-21&utm_campaign=3-12-21" target="_blank">Best for boosters of 6 vaccines tested</a></p>
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<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><span style="font-size: 12pt;">Moderna/NIAID
- US </span><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021" style="font-size: 12pt;"><span style="color: blue;">Prescribing info</span></a><br />'<a href="https://www.precisionvaccinations.com/2021/07/10/europe-confirms-mrna-vaccines-can-cause-heart-disease?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Spikevax</a>'</span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">mRNA spike</span></a><o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">100% @30mcg</span></a><o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">94.</span></a>1% after 2 doses<o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">FDA Dec 17</span></a><br />
<span style="color: blue;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021">EU Jan 6</a><br /><a href="http://www.pmlive.com/pharma_news/uk_approves_modernas_covid-19_vaccine,_secures_another_10_million_doses_1360974?utm_source=pmlive&utm_medium=email&utm_campaign=weekinreview&" target="_blank">UK Jan 8</a><br /><a href="https://www.precisionvaccinations.com/spikevax-vaccine-approved-us-fda?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Full FDA Approval</a> <br />1/31/22</span><o:p></o:p></span></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Oxford/Astra
Zeneca - UK<br />
<span style="color: blue;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021">ChAdOx1</a></span><o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">'<a href="https://www.ema.europa.eu/en/medicines/dhpc/vaxzevria-previously-covid-19-vaccine-astrazeneca-risk-thrombocytopenia-coagulation-disorders" target="_blank">Vaxzevria</a>'</span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;">'<a href="https://www.bbc.com/news/world-asia-india-55748124" target="_blank">Covishield</a>'</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">Chimp adenovirus vectors </span></a>- spike <o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Germany approve use only in under 65s due to lack of data<o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Over 65s now getting it preferentially due to<a href="https://osf.io/a9jdq/" target="_blank"> blood clots in younger subjects</a>. </span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">70.4% overall</span></a><br />
(90% w/low-high dose regimen)<br /><a href="https://www.reuters.com/article/idUSKBN2B319K" target="_blank">11-03-21 EU countries suspend use due to clots</a><o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><span style="color: blue;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021">UK 30 Dec</a><br /></span></span><a href="https://www.irishtimes.com/business/health-pharma/astrazeneca-covid-19-vaccine-wins-approval-from-eu-regulator-1.4470869" style="font-family: "Times New Roman", serif; font-size: 12pt;" target="_blank">EU Jan 29</a></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.smithsonianmag.com/smart-news/revised-astrazeneca-data-show-its-covid-19-vaccine-76-percent-effective-180977356/" target="_blank">US submission 25/03/21</a></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Several countries hold off due to <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00762-5/fulltext" target="_blank">rare blood clots</a>. <br /><a href="https://www.precisionvaccinations.com/2021/05/21/vaxzevria-covid-19-vaccine-granted-special-approval-japan?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Approved in Japan and sublicensed to 165 countries.</a><o:p></o:p></span></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Gamaleya (Russia)<br />
'<a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">Sputnik V</span></a>'<o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">Human adenovirus vector</span></a> - 2 spike<o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31866-3/fulltext">100%
seroconversion</a><o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><span>91.4%</span> </span>after 2 doses <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00234-8/fulltext" target="_blank">Lancet</a><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">Russia approved</span></a> in <a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30402-1/fulltext">Aug
2020</a><br /><a href="https://www.euronews.com/2021/03/04/ema-starts-review-of-russian-developed-sputnik-covid-vaccine?utm_source=newsletter&utm_medium=en&utm_content=ema-starts-review-of-russian-developed-sputnik-covid-vaccine&_ope=eyJndWlkIjoiYjlhOGRmYmIyMDQwOTllOThkZjgwMmViMDE4NmFhNGQifQ%3D%3D" target="_blank">EMA reviews Mar 2021</a><o:p></o:p></span></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="http://www.pmlive.com/pharma_news/curevac_set_to_begin_phase_3_covid-19_vaccine_study_in_healthcare_workers_1360354" style="font-size: 12pt;" target="_blank">CureVac</a> (Germany)<br /></span>CVnCoV</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://horizon-magazine.eu/article/so-far-so-good-view-inside-coronavirus-vaccine-trial.html" target="_blank">mRNA</a></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;">May c<a href="https://www.ft.com/content/5f7a63a8-7cfb-4c2f-9719-980d19ff080f" target="_blank">over variants</a> - no need for sub-zero</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.clinicaltrialsarena.com/news/curevac-begins-vaccine-trial/" target="_blank">2 dose schedule</a></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.gov.uk/government/news/new-vaccines-partnership-to-rapidly-respond-to-new-virus-variants" target="_blank">Deal w/UK</a> to focus on variants<br /></span><a href="https://www.fiercepharma.com/pharma/europe-s-vaccine-rollout-slagging-after-j-j-and-az-holdups-curevac-readies-doses-for" style="font-family: "Times New Roman", serif; font-size: 16px;" target="_blank">Has begun production</a>- Phase 3 fully enrolled</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.irishtimes.com/business/health-pharma/how-vaccine-laggard-curevac-hopes-to-come-out-on-top-1.4493799" target="_blank">EU begins review</a> 03/21 </span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.nytimes.com/2021/05/05/health/covid-vaccine-curevac.html?action=click&module=Top%20Stories&pgtype=Homepage" target="_blank">Phase 3 ends mid-May</a></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.reuters.com/business/healthcare-pharmaceuticals/curevac-says-mass-vaccine-rollout-thrown-into-doubt-by-us-restrictions-2021-05-04/" target="_blank">Supply a challenge</a></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 12pt; mso-margin-top-alt: auto;">Sanofi/Translate Bio</p></td><td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135"><a href="https://www.reuters.com/article/us-health-coronavirus-sanofi-vaccine/sanofi-translate-bio-launch-human-trial-of-mrna-covid-19-vaccine-idUSKBN2B40J4" target="_blank">mRNA</a></td><td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">1 or 2 doses</td><td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">Phase 1/2 Trials initiated<br />03/21</td><td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108"></td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Sanofi/GSK<o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> <a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">rDNA/adjuvant</span></a><o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">89.6%
18-49 yo<br />
85% >50<br />
62.5% >60<br /><br /><a href="https://www.reuters.com/business/healthcare-pharmaceuticals/sanofigsk-report-positive-interim-results-their-covid-19-shot-2021-05-17/" target="_blank">Interim results</a> w/new formulation = 95-100% seroconversion <o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">Manufacturing <br />
issue - reformulation</span></a><o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">Delayed</span></a> due to <a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">poor response</span></a> in older subjects 11/12/20<br />Trials restarted 02/21<o:p></o:p></span></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Novavax <br /><a href="NVX-CoV2373" target="_blank">NVX-CoV2373</a><o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;">(Nuvaxovid, CovoVax) </p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.precisionvaccinations.com/vaccines/novavax-nuvaxovid-covid-19-vaccine" target="_blank">Covid-NanoFlu combination vaccine</a></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">rDNA/Matrix-M™
adjuvant:<br />
baculovirus spike nanoparticles<o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Production by India's SII the world's largest producer of vaccines by volume</span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">100%</span></a> after dose 2<o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://finance.yahoo.com/video/novavax-covid-19-vaccine-candidate-211452810.html" target="_blank">96.4% effective against original strain in UK trial, 86% UK, 55% SA</a> strains<br /><o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.biorxiv.org/content/10.1101/2021.06.08.447631v1" target="_blank">Effective as booster against variants</a></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3" target="_blank">89.3% in </a>US/Mex<br /><a href="https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3">60% in SA</a><br /><a href="https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3" target="_blank">89.3% UK</a></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2103055?query=TOC" target="_blank">60% in SA</a> in HIV neg subj</p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.nytimes.com/2021/06/14/health/covid-vaccine-novavax.html?referringSource=articleShare" target="_blank">90.4% Efficacy in US Phase 3</a></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.precisionvaccinations.com/2021/12/16/marylands-covid-19-vaccine-found-very-effective?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Phase 3 complete</a></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">Delayed</span></a> (Q3)</span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.medscape.com/viewarticle/950865?src=wnl_edit_tpal&uac=18825DR&impID=3369780&faf=1" target="_blank">Delayed again</a> (Q4)<br /></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;">EMA started a rolling review of NVX-CoV2373 in early 2021<br /><br /><a href="https://www.precisionvaccinations.com/2021/11/04/marylands-covid-19-vaccine-files-who?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Novavax filed for WHO approval. 4 Nov 2021</a><br /><br /><a href="https://www.precisionvaccinations.com/vaccines/novavax-nuvaxovid-covid-19-vaccine" target="_blank">EU approved 20 Jan 2022</a> - shipping to EU Feb 23</p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.precisionvaccinations.com/2022/09/02/europe-recommends-protein-based-covid-19-booster-adults?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">EU approved as booster</a></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.nytimes.com/2021/01/07/business/china-coronavirus-vaccine-sinovac.html?referringSource=articleShare">Sinopharm</a>
(China)<br />
<!--[if !supportLineBreakNewLine]--><br />
<!--[endif]--><o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Inactivated
virus<o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> </span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">79.34%<o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">China
approved Dec31<br /><a href="https://www.euronews.com/2021/03/11/serbia-to-produce-chinese-covid-19-vaccine" target="_blank">Serbia to produce</a><o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://www.bbc.com/news/world-asia-china-56967973" target="_blank">WHO approved </a>07-05-21</p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><a href="https://jamanetwork.com/journals/jama/fullarticle/2780562?guestAccessKey=a7a785c0-c695-4353-b4a0-73089c44ffaf&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=052621" target="_blank">Clin Trial results</a> JAMA 26/5/21</p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.nytimes.com/2021/01/07/business/china-coronavirus-vaccine-sinovac.html?referringSource=articleShare">Sinovac</a>
(China) –<br />
CoronaVac<o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">Inactivated
virus - </span><span style="font-family: "Times New Roman", serif; font-size: 12pt;">2</span><sup style="font-family: "Times New Roman", serif;">nd</sup><span style="font-family: "Times New Roman", serif; font-size: 12pt;">
vaccine in China</span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> </span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.bbc.com/news/world-latin-america-55642648" target="_blank">50.4% Brazil, </a>78% Brazil, 65.3% Indonesia, 91.25 Turkey<o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"> WHO approval expected 03/21</span></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-top-alt: solid windowtext 1.0pt; padding: 0cm 5.4pt; width: 106.15pt;" valign="top" width="142">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 12pt; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><span style="font-size: 12pt;"><a href="https://www.jnj.com/innovation/making-johnson-johnson-janssen-covid-19-vaccine" target="_blank">J&J
/Janssen</a> (US)</span><br />Ad26.COV2.S </span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 12pt; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">
<br />
<!--[if !supportLineBreakNewLine]--><br />
<!--[endif]--><o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 101.15pt;" valign="top" width="135">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;">AdVac® <a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">human attenuated adenovirus</span></a> vectors
carrying complete spike protein rDNA<o:p></o:p></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 89.5pt;" valign="top" width="119">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">98%</span></a> After 1 dose, 100% in interim results </span><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2034201?query=featured_home" style="font-family: "Times New Roman", serif; font-size: 12pt;" target="_blank">1 vs 2 dose trial</a></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 85.15pt;" valign="top" width="114">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.blogger.com/blog/post/edit/25393536747247227/5310167287895741021"><span style="color: blue;">enrolment completed</span></a> -<br />57-72% effective in protecting against mod-sev Covid-19 28d after 1 dose<br /><o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; mso-margin-top-alt: auto;"><span style="font-family: "Times New Roman",serif; font-size: 12pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-GB;"><a href="https://www.medscape.com/viewarticle/954669?src=mkm_covid_update_210712_MSCPEDIT&uac=18825DR&impID=3501376&faf=1" target="_blank">Risk of Guillain-Barré syndrome</a></span></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; padding: 0cm 5.4pt; width: 80.8pt;" valign="top" width="108"><a href="https://www.jnj.com/johnson-johnson-covid-19-vaccine-authorized-by-u-s-fda-for-emergency-usefirst-single-shot-vaccine-in-fight-against-global-pandemic" target="_blank">US approved Jan 27</a><br /><a href="https://www.rte.ie/news/2021/0216/1197496-j-j-vaccine-ema/" target="_blank">EU applied 16/02/21</a><br /><a href="https://www.rte.ie/news/2021/0311/1203274-europe-coronavirus/" target="_blank">EU approved 11-03-21</a><br /><br /><a href="https://www.npr.org/2021/03/03/973117712/how-the-white-house-got-2-pharma-foes-to-work-together-on-covid-19-vaccine" target="_blank">Merck/Sanofi/others to help manufacture</a>, fill & pack<br /><br />J&J temp suspended release due to rare blood clots in younger, mostly women. </td>
</tr>
</tbody></table><table border="1" cellpadding="0" cellspacing="0" class="MsoTableGrid" style="border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt; mso-yfti-tbllook: 1184;">
<tbody><tr>
<td style="border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Novavax </o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.precisionvaccinations.com/2021/10/18/influenza-coronavirus-combo-vaccine-demonstrated-robust-immune-responses?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">COVID-NanoFlu™</a></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Combination vaccine - recombinant nanoparticle protein-based COVID-19 and NanoFlu™ vaccines with Matrix-M™ adjuvant</p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p></td><td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120"><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><br /></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Walvax Biotechnology (China)</o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>ARCoV </o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p><br /></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> mRNA vaccine</o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p><a href="https://www.reuters.com/business/healthcare-pharmaceuticals/chinas-walvax-says-has-most-participants-large-mrna-covid-vaccine-trial-2022-01-27/?taid=61f2b703f006770001ad0097&utm_campaign=trueanthem&utm_medium=trueanthem&utm_source=twitter" target="_blank">Recruited 28,000 patients for phase 3 trial.</a> </o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Also recruited 1000 patients for booster trial. </o:p></p>
</td>
</tr>
</tbody></table><br /><br /><table border="1" cellpadding="0" cellspacing="0" class="MsoTableGrid" style="border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt; mso-yfti-tbllook: 1184;">
<tbody><tr>
<td style="border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">APC/Vaxine<br />CoVax-19</p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://approcess.com/blog/irish-company-apc-partners-with-australian-biotechnology-firm-vaxine-to-accelerate-the-development-and-delivery-of-new-covid-19-vaccine-candidate">Advanced
tech with Advax-SM adjuvant</a><o:p></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Phase 2 initiated<o:p></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.irishtimes.com/business/health-pharma/irish-pharma-company-apc-invests-25m-in-vaccine-manufacture-1.4589530?mode=sample&auth-failed=1&pw-origin=https%3A%2F%2Fwww.irishtimes.com%2Fbusiness%2Fhealth-pharma%2Firish-pharma-company-apc-moves-into-vaccine-manufacture-1.4589530">Manufacturing</a>
scale-up in Dublin<o:p></o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><span style="font-family: "Times New Roman", serif;">Valneva (France)</span></p><span style="font-family: "Times New Roman", serif;">VLA2001 </span><span style="font-family: "Times New Roman", serif;"> </span>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">inactivated adjuvanted whole virus vaccine</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">89.8% in the medium-dose and 100% in the high-dose group after 2 doses</p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">95% response</p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://valneva.com/press-release/valneva-reports-positive-phase-3-results-for-inactivated-adjuvanted-covid-19-vaccine-candidate-vla2001/" target="_blank">95% seroconversion</a></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://valneva.com/press-release/valneva-reports-positive-phase-1-2-data-for-its-inactivated-adjuvanted-covid-19-vaccine-candidate-vla2001/" target="_blank">Phase 1/2 results positive</a></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://valneva.com/press-release/valneva-reports-positive-phase-3-results-for-inactivated-adjuvanted-covid-19-vaccine-candidate-vla2001/" target="_blank">Phase 3 better response than AZ vaccine</a> - sig better tolerability</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Phase 3 trial <a href="https://www.reuters.com/world/europe/exclusive-some-eu-nations-still-want-valneva-covid-19-vaccine-deal-sources-2021-04-30/" style="font-family: "Times New Roman", serif; font-size: 16px;" target="_blank">underway </a></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.precisionvaccinations.com/2021/10/18/inactivated-adjuvanted-covid-19-vaccine-candidate-compares-very-well?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Completed and showed superior response</a> to AZ vaccine and good antibody response. </p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><br /></p>
</td>
</tr>
</tbody></table><div><table border="1" cellpadding="0" cellspacing="0" class="MsoTableGrid" style="border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt; mso-yfti-tbllook: 1184;">
<tbody><tr>
<td style="border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Zydus Cadila <br />
ZyCoV-D <br /><a href="https://www.precisionvaccinations.com/vaccines/zycov-d-covid-19-vaccine" target="_blank">India</a><o:p></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">1<sup>st</sup>
plasmid DNA vaccine (3 dose)<br />
<!--[if !supportLineBreakNewLine]--><br />
<!--[endif]--><o:p></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Clin trials
in 50 centers<br />
<a href="https://www.precisionvaccinations.com/2021/07/01/first-plasmid-dna-vaccine-covid-19-prepares-launch?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=%5b%20_currentdayname%5d">applied
for emergency use</a><o:p></o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>HDT Bio Corp<br /></o:p>HDT-301 COVID-19 RNA<br />USA</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Lipid InOrganic Nanoparticle (LION) - protects against variants</o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p><a href="https://www.precisionvaccinations.com/2021/07/02/2nd-generation-mrna-vaccine-candidate-confirms-phase-1-study?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Phase 1 in 60 patients - 2 dose</a></o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Medicago, Canada<br /></o:p>Covifenz</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>1st plant-based vaccine </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>plant related to tobacco manufactures a protein similar to spike</o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>71% effective against infection </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p><a href="https://www.nytimes.com/2022/02/26/world/canada/canada-covifenz-vaccine-mrna.html" target="_blank">Approved</a> in Canada Feb 25</o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
</tr>
</tbody></table></div><div><span style="white-space: pre;"> </span></div><div><span style="white-space: pre;"><br /></span></div><div><span style="white-space: pre;"> </span></div><table border="1" cellpadding="0" cellspacing="0" class="MsoTableGrid" style="border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt; mso-yfti-tbllook: 1184;">
<tbody><tr>
<td colspan="5" style="border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 450.8pt;" valign="top" width="601">
<p align="center" class="MsoNormal" style="line-height: normal; margin-bottom: 0cm; text-align: center;">Multivalent, Multiviral Vaccines<o:p></o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Moderna <br />
mRNA-1010<o:p></o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Quadrivalent
flu<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Phase 1 <br />
50 mcg, 100 mcg, 200 mcg<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.precisionvaccinations.com/2021/12/10/mrna-flu-shot-candidate-announces-positive-results?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=%5b%20_currentdayname%5d">GMT
against all strains at 29 days</a><o:p></o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">A/H1N1,
A/H3N2, influenza B/Yamagata- and B/Victoria-lineages<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://investors.modernatx.com/news/news-details/2021/Moderna-Announces-Positive-Interim-Phase-1-Data-for-mRNA-Flu-Vaccine-and-Provides-Program-Update/default.aspx">Phase
2 trial fully enrolled</a><o:p></o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Phase 3 prep
underway<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Moderna<o:p></o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">mRNA-1011<br />
mRNA-1012<o:p></o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Multivalent
flu<o:p></o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://investors.modernatx.com/news/news-details/2021/Moderna-Announces-Positive-Interim-Phase-1-Data-for-mRNA-Flu-Vaccine-and-Provides-Program-Update/default.aspx">Strategic
planning</a> mRNA<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Moderna<o:p></o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">mRNA-1020<br />
mRNA-1030<o:p></o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Sars-CoV-2/Flu/RSV
booster<o:p></o:p></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://investors.modernatx.com/news/news-details/2021/Moderna-Announces-Positive-Interim-Phase-1-Data-for-mRNA-Flu-Vaccine-and-Provides-Program-Update/default.aspx">Strategic
planning</a><o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p><a href="https://www.army.mil/article/252890/series_of_preclinical_studies_supports_the_armys_pan_coronavirus_vaccine_development_strategy" target="_blank">US Army <br />Walter Read</a></o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>SpFN</o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.defenseone.com/technology/2021/12/us-army-creates-single-vaccine-effective-against-all-covid-sars-variants/360089/" target="_blank">Phase I study completed</a> </p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Spike Ferritin Nanoparticle COVID-19 vaccine</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Elicits antibodies that are expected to protect against all known strains and variants of coronaviruses incl Covid and SARS</o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120"></td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
</tr>
</tbody></table><div><span style="white-space: pre;"> </span></div><div><span style="white-space: pre;"> </span></div><div><br /></div>The <a href="https://cen.acs.org/pharmaceuticals/vaccines/Adenoviral-vectors-new-COVID-19/98/i19" target="_blank">story of adenoviral vector vaccines</a> and prior immunity to adenovirus. </div><div><br /></div><div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXzf_vQSCsvyal0Go_WF_oxwRqV_iZF31-6_EQjlHgZK5qoWUTAsV3mT2JWLPXTRDHby0PS5fu-6v5b19wHm1Zk34W7pCKRN1Jkm3cAZjG0wKaJm3oV_SbkzsybPeZnv4QChNlq62bHTE/s814/corona_vax_vials.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="600" data-original-width="814" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXzf_vQSCsvyal0Go_WF_oxwRqV_iZF31-6_EQjlHgZK5qoWUTAsV3mT2JWLPXTRDHby0PS5fu-6v5b19wHm1Zk34W7pCKRN1Jkm3cAZjG0wKaJm3oV_SbkzsybPeZnv4QChNlq62bHTE/s320/corona_vax_vials.jpg" width="320" /></a></div><br /><div><a href="https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines" target="_blank">WHO Coronavirus vaccine landscape</a> tracks 173 vaccines in development, 64 have reached clinical trials. </div><div><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjBDbXTHuR5rJgpY0iB7p653lIjQLkQ-HhCN8u6pQmMs970Pm6akkASL1PBzUTTYX8LZIbmBSDaA2l_rGUHnVBMwPyfW-mVlcTFbeE2kNc0PlK54d4ILj5uFBFSfHnxJbrpPxFB1FJ0Yls/s895/Screenshot+%2528371%2529.png" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="895" data-original-width="867" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjBDbXTHuR5rJgpY0iB7p653lIjQLkQ-HhCN8u6pQmMs970Pm6akkASL1PBzUTTYX8LZIbmBSDaA2l_rGUHnVBMwPyfW-mVlcTFbeE2kNc0PlK54d4ILj5uFBFSfHnxJbrpPxFB1FJ0Yls/w388-h400/Screenshot+%2528371%2529.png" width="388" /></a></div><div><br /></div><a href="https://apnews.com/article/coronavirus-pandemic-5e0de4fdbceea5b2517af7c7846aff5c?utm_source=Twitter&utm_medium=AP&utm_campaign=SocialFlow" target="_blank">Merck</a> drops two candidate vaccines due to poor results in early-stage trials. <div><br /></div><div>AZ vaccine data lacking in over 65. </div><div><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhgsU9MZIvtNUnK4cm_ePocVjYB5uDT_M7jyE5_wMF7koO5t5XC3YlIFchbUpa6ie0Y9aCF8zZG6b3QRo4AbHMawbrA7HyogCTNZvzIyDL3CKgPcOFAFKEF4x_YA-ZH8XX56t9KAA-gpdM/s604/Es5vTBlWMAAP5vM.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="210" data-original-width="604" height="139" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhgsU9MZIvtNUnK4cm_ePocVjYB5uDT_M7jyE5_wMF7koO5t5XC3YlIFchbUpa6ie0Y9aCF8zZG6b3QRo4AbHMawbrA7HyogCTNZvzIyDL3CKgPcOFAFKEF4x_YA-ZH8XX56t9KAA-gpdM/w400-h139/Es5vTBlWMAAP5vM.jpg" width="400" /></a></div><br /><div>Coronavirus stats <a href="https://www.worldometers.info/coronavirus/" target="_blank">Worldometer</a> and <a href="https://coronavirus.jhu.edu/map.html" target="_blank">Johns Hopkins</a><br /><div>Animated <a href="https://www.rferl.org/a/animated-graphic-coronavirus-deaths-week-by-week/30925716.html" target="_blank">graphic </a>covid-related deaths by week</div></div><div>Animated <a href="https://nymag.com/intelligencer/2020/04/the-rapid-increase-of-u-s-coronavirus-deaths-in-one-graphic.html" target="_blank">graphic</a> shows deaths due to Covid-19 vs other causes over time</div><div><br /></div><div><a href="https://www.statista.com/chart/24191/number-of-countries-using-selected-covid-19-vaccines/" target="_blank">Which vaccines</a> are in use around the world - Feb 2021. </div><div> </div><div><a href="https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html?action=click&module=Top%20Stories&pgtype=Homepage" target="_blank">NYT Vaccine Status Tracker</a></div><div><br /></div><div><a href="https://www.irishtimes.com/news/health/covid-19-vaccine-tracker-what-s-available-in-the-republic-of-ireland-and-what-else-is-coming-1.4481095" target="_blank">RTE Vaccine Tracker</a> </div><div><br /></div><div><a href="https://www.precisionvaccinations.com/2021/05/22/covid-19-vaccine-breakthrough-fatalities-and-hospitalizations-increased?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Breakthrough infections reported</a> mainly in over 65s</div><div><br /></div><div><a href="https://www.precisionvaccinations.com/2021/06/03/inactivated-covid-19-vaccine-candidate-launches-phase-3-study?utm_source=newsletter&utm_campaign=pv-consumer-general&utm_medium=email&utm_content=[%20_currentdayname]" target="_blank">Cov-Boost Trial</a> in UK is evaluating 7 different vaccines as boosters. Data due Sep 2021.</div><div><br /></div><div><span style="font-size: large;">Treatments</span></div></div><div><table border="1" cellpadding="0" cellspacing="0" class="MsoTableGrid" style="border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt; mso-yfti-tbllook: 1184;">
<tbody><tr>
<td style="border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Veklury
(remdesivir)<o:p></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2007764">Gilead</a> <o:p></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">IV 10 days<o:p></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Shorter time
to recovery and less progression to severe disease<o:p></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Viral RNA
polymerase inhibitor<o:p></o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Lageviro (molnupiravir)<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.inquirer.com/health/coronavirus/covid-19-viruses-tougher-than-bacteria-to-treat-20210312.html">Merck</a><o:p></o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">50 % effective given within 5 days of the onset of symptoms</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">PO <o:p></o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">40 pills over five days</p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">5 days no
detectable virus<o:p></o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.reuters.com/business/healthcare-pharmaceuticals/merck-covid-19-pill-sparks-calls-access-lower-income-countries-2021-10-17/" target="_blank">Cut death and hospitalization by 50% </a></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.fiercebiotech.com/biotech/merck-has-better-luck-second-covid-drug-attempt-as-it-sees-a-positive-early-molnupiravir">nucleoside
analog antiviral</a><o:p></o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.axios.com/merck-fda-approval-antiviral-covid-19-pill-26ca000c-2325-4a3c-9cf4-21567a5dfe3f.html" target="_blank">Filed for approval.</a></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.nytimes.com/2021/11/04/business/britain-covid-merck-antiviral.html" target="_blank">Approved in UK 4 Nov 2021</a></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.medscape.com/viewarticle/965484?uac=18825DR&faf=1&sso=true&impID=3898907&src=mkm_covid_update_211223_MSCPEDIT" target="_blank">Approved in US Dec 23</a></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Yeliva
(opaganib)<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.redhillbio.com/opaganibcovid19">RedHill Biopharma</a><o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">PO<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Reduces need
for oxygen in hospitalised patients<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">sphingosine
kinase-2 (SK2) selective inhibitor<o:p></o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">upamostat<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.redhillbio.com/rhb-107">RedHill Biopharma</a><o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">PO<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Serine protease
inhibitor <a href="https://www.prnewswire.com/in/news-releases/redhill-biopharma-announces-first-patient-dosed-in-u-s-phase-2-3-covid-19-outpatient-study-with-rhb-107-866409803.html">Phase
2/3 trial</a><o:p></o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">bamlanivimab/etesevimab<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.prnewswire.com/news-releases/lillys-bamlanivimab-and-etesevimab-together-reduced-hospitalizations-and-death-in-phase-3-trial-for-early-covid-19-301243984.html">Lilly</a><o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">IV infusion<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Reduces risk
of hospitalisation and death by 87%<o:p></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;">Mab<o:p></o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><a href="https://www.ema.europa.eu/en/news/ema-ends-rolling-review-antibodies-bamlanivimab-etesevimab-covid-19-following-withdrawal-lilly" target="_blank">Lilly withdrew from EMEA rolling review</a></p>
</td>
</tr>
</tbody></table></div><div><span style="font-size: large;"><table border="1" cellpadding="0" cellspacing="0" class="MsoTableGrid" style="border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt; mso-yfti-tbllook: 1184;">
<tbody><tr>
<td style="border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Paxlovid (PF-07321332 +ritonavir)</o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> <a href="https://www.nytimes.com/2021/11/05/health/pfizer-covid-pill.html" target="_blank">Pfizer</a></o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> PO</o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>30 pills given over five days<br />(3 pills b.i.d.)</o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>89% effective at preventing hospitalization or death if given within 3 days of symptom onset </o:p></p>
</td>
<td style="border-left: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> protease inhibitor</o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p><a href="https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-oral-antiviral-treatment-covid-19" target="_blank">FDA approved Dec 22, 2021</a></o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Xevudy (sotrovimab antibody cocktail)</o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
GlaxoSmithKline (GSK) with U.S. partner Vir
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>IV Infusion over 30 min</o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p><a href="https://www.reuters.com/business/healthcare-pharmaceuticals/gsk-says-tests-show-antibody-drug-works-against-omicron-2021-12-02/?utm_source=Sailthru&utm_medium=email&utm_term=The%20Reuters%20Daily%20Briefing&utm_content=2-12-21&utm_campaign=2-12-21" target="_blank">retains effectiveness against Omicron variant</a></o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Monoclonal antibodies</o:p></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p><a href="https://www.theguardian.com/world/2021/dec/02/uk-drugs-watchdog-approves-new-covid-treatment-xevudy" target="_blank">Approved in UK</a></o:p></p>
</td>
</tr>
<tr>
<td style="border-top: none; border: 1pt solid windowtext; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p><a href="https://www.reuters.com/business/healthcare-pharmaceuticals/regeneron-says-covid-19-drug-could-be-less-effective-against-omicron-variant-2021-11-30/" target="_blank">Regeneron</a> and AstraZeneca </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p> </o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.15pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>May be less effective against Omicron variant</o:p></p>
</td>
<td style="border-bottom: 1pt solid windowtext; border-left: none; border-right: 1pt solid windowtext; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt; width: 90.2pt;" valign="top" width="120">
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0cm;"><o:p>Monoclonal antibodies</o:p></p>
</td>
</tr>
</tbody></table></span></div><br />Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-45206973948646100132021-10-02T13:09:00.006+01:002021-10-02T16:27:15.599+01:00US surpasses 700,000 deaths due to Covid<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiupwK_jQBl49rWn5b177GUJN9Xr0-rJKGbOh-gc_prNqkocj3Bh2_yYyfMB2-HxxfH3rPL0jNxGVhOYxkdTA6jNxxjkmQpNhB5RldneyvqNWOwpV8IQkIKaAfO5Or2_1aZcBZNOuU7CVI/s1216/_20211001_on_molnupiravirlinky.jpg" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="804" data-original-width="1216" height="212" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiupwK_jQBl49rWn5b177GUJN9Xr0-rJKGbOh-gc_prNqkocj3Bh2_yYyfMB2-HxxfH3rPL0jNxGVhOYxkdTA6jNxxjkmQpNhB5RldneyvqNWOwpV8IQkIKaAfO5Or2_1aZcBZNOuU7CVI/s320/_20211001_on_molnupiravirlinky.jpg" width="320" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Merck's Molnupiravir oral antiviral drug</td></tr></tbody></table><p>As the world approaches 5 million confirmed dead due to Covid-19, the US passes 700,000 with no signs of slowing down. More than 235 million are confirmed to have contracted the disease, though the number is probably much higher in reality. Just thinking that both India's and China's populations are around 1.4 billion, then 235 million is a drop in the bucket. This thing is going to be with us for a long time. </p><p>When you think that the Spanish flu in 1918-1919 killed somewhere around 50,000,000 globally but only about 675,000 in the US, we're doing a helluva a lot better globally, probably because of the vaccine and known precautions. </p><p>The worry is that flu will rear its head this year, so I've already had my vaccination. Europe approved Fluad Tetra which I had not heard of. It is a surface antigen subunit vaccine with adjuvant. Europe indicated it for over 65s as it has better efficacy. But I was taken aback when they described it as being for the elderly. Then it dawned on me that, at 67, I am considered elderly. But there are so many people older than me now that I just don't feel that old. Maybe I never will. Observational studies among Medicare beneficiaries 65 years and older found that trivalent Fluad provided greater protection against flu-related hospitalizations and emergency department visits than standard-dose, egg-based quadrivalent flu vaccine. Data comparing the effectiveness of Fluad Quadrivalent with standard-dose unadjuvanted inactivated vaccines are not yet available.</p><p>I am scheduled for the pneumococcal vaccine on Tuesday. We will probably be advised to get a Covid booster soon, for which I will be among the first in line. </p><p>The great news is that Merck has developed an antiviral drug called <a href="https://www.science.org/content/article/unquestionably-game-changer-antiviral-pill-cuts-covid-19-hospitalization-risk?utm_campaign=news_weekly_2021-10-01&et_rid=40181025&et_cid=3941861" target="_blank">Molnupiravir </a>which cuts the rate of <a href="https://www.merck.com/news/merck-and-ridgebacks-investigational-oral-antiviral-molnupiravir-reduced-the-risk-of-hospitalization-or-death-by-approximately-50-percent-compared-to-placebo-for-patients-with-mild-or-moderat/" target="_blank">hospitalisation and death by 50%</a>. I think it's the first new antiviral in years and it's oral. They will be going for emergency use authorisation and have priced the drug at $700 a course, which is less than monoclonal antibody therapy but still not like penicillin. Of course, you have to catch the infection early, as with other antivirals. But they are calling it a game-changer. It takes 4 capsules 2x/day for 5 days - 40 capsules in total. It stops the virus from replicating by <a href="https://www.nytimes.com/live/2021/09/30/world/covid-delta-variant-vaccines#merck-antiviral-pill-covid " target="_blank">inserting errors</a> into its genetic code. I'll have to read more about that MOA. </p><p><br /></p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-16345017336444424112021-09-18T11:13:00.004+01:002021-09-18T16:29:50.769+01:00US Surpasses 1 in 500 Deaths due to Covid-19<p>"<span style="font-family: georgia, "Times New Roman", serif; font-size: 20px;">At a certain point, it was no longer a matter of </span><i style="-webkit-font-smoothing: antialiased; box-sizing: border-box; font-family: georgia, "Times New Roman", serif; font-size: 20px;">if</i><span style="font-family: georgia, "Times New Roman", serif; font-size: 20px;"> the United States would reach the gruesome milestone of 1 in 500 people dying of covid-19, but a matter of when. A year? Maybe 15 months? The answer: 19 months."</span></p>From the <a href="https://www.washingtonpost.com/health/interactive/2021/1-in-500-covid-deaths/?pwapi_token=eyJ0eXAiOiJKV1QiLCJhbGciOiJIUzI1NiJ9.eyJzdWJpZCI6IjE5NDM4MTgyIiwicmVhc29uIjoiZ2lmdCIsIm5iZiI6MTYzMTc5NTA0NiwiaXNzIjoic3Vic2NyaXB0aW9ucyIsImV4cCI6MTYzMzAwNDY0NiwiaWF0IjoxNjMxNzk1MDQ2LCJqdGkiOiIxYjQ0YWExMy01M2I0LTRmYWUtODA2Zi03MjY2ZTUwYjdjMmIiLCJ1cmwiOiJodHRwczovL3d3dy53YXNoaW5ndG9ucG9zdC5jb20vaGVhbHRoL2ludGVyYWN0aXZlLzIwMjEvMS1pbi01MDAtY292aWQtZGVhdGhzLyJ9.XY1gn_njw7nsR49fmv_GN83JoR83y25IYzm5TUefU5Y&itid=gfta&utm_campaign=58ed4acdb4-briefing-dy-20210916&utm_medium=email&utm_source=Nature+Briefing&utm_term=0_c9dfd39373-58ed4acdb4-44673205" target="_blank">Washington Post</a> today, what a gruesome fact about the country of my birth, the land of liberty. And this weekend, organisers of a rally in DC are protesting the punishment of the insurrectionists who led the assault on Capitol Hill on January 6. What has happened to America? Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-62249254007311985922021-08-14T14:13:00.000+01:002021-08-14T14:13:04.675+01:00So much sorrow<p>Early this week, our friends came over to see the garden and the new mowing machinery as they are thinking of getting something similar. That evening they received a message saying goodbye from their son. They learned later that he had jumped off a cliff. His body was recovered the next day by the subaqua police. They are gutted. His cremation service was yesterday. We did not go. </p><div>Yesterday, I learned that a friend from my last job who I had stayed in touch with over the years had died of cancer aged 60. We are now at the age when we lose friends and family regularly. </div><div><br /></div><div>4.36 M have died of confirmed coronavirus infection but the real figure must be many times that. So many sad people have lost so much more. </div>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-78624684370902316602021-08-14T14:10:00.004+01:002021-10-02T13:22:22.090+01:00Bad news<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgmTgWn8xsypRSg9Lj4OCMdtlxn3IA6EkwQt-wRh3nWItkUmj94qHubQRWkD0pSq0wM840Bpx33RDDtgmSMYPvvvAR88ZXj3B8Jo8JeJXPpnNaGFzPgo5FcOasOpwHMeUfpqiP8mKCwRyg/s2048/20210814_121735.jpg" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="1536" data-original-width="2048" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgmTgWn8xsypRSg9Lj4OCMdtlxn3IA6EkwQt-wRh3nWItkUmj94qHubQRWkD0pSq0wM840Bpx33RDDtgmSMYPvvvAR88ZXj3B8Jo8JeJXPpnNaGFzPgo5FcOasOpwHMeUfpqiP8mKCwRyg/s320/20210814_121735.jpg" width="320" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Easter 2004 Mahwah NJ: Oksy, Walt, Mom and me<br />The last time we were all together.</td></tr></tbody></table><br /><p>On the 1st of August, my brother, Walt aka Dy, sent me an email:</p><p>'Letting you know that I am now entering final home hospice care for my cancer. This week turned to final stages.</p><p>Will transition from home to hospital hospice care as necessary</p><p>DO NOT plan on coming here</p><p>There will be cremation but no funeral services</p><p>Call Mira and Dorian' </p><div>We've known it was coming as he's been undergoing chemo and radiation treatments for 3 years. He was diagnosed with stage 4 rectal cancer. Now that the chemo is no longer working, he will be gone in a few days. I got to speak with him but cannot see him. I haven't actually seen him in several years. He's an extreme introvert as is his wife, Mira, and son, Dorian, who lived with us for 6 months as a school work project. </div><div><br /></div><div>It's hardest on Dorian, who has been taking care of both of them for years now. Mira had back surgery and chronic TMJ pain. Dy has been in and out of the cancer ward for years. Dorian is so tired and distraught and I can't be there to hug or help. It sucks. He can't stand watching his father suffer even more than he has for so long. </div><div><br /></div><div>And now I just learned that my brother passed peacefully in his sleep during the night. RIP Walt, my brother. I hope Oksy is on your case. Now I am an only. </div><div><br /></div><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiGSkowZyBJYVDmJIPcvszRDLQ1nN6G3Cdmkj0CjJTNVJmSxDbcurUONnqOC4FB3hj_oBD3ULPsTK_oHLGRa48lTWp3yO7JyovZs1oBZg3aP7gOU5J5Vavgd5vGx4fLVdJ6wcMe4Pn7TKE/s865/WaltK.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="700" data-original-width="865" height="259" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiGSkowZyBJYVDmJIPcvszRDLQ1nN6G3Cdmkj0CjJTNVJmSxDbcurUONnqOC4FB3hj_oBD3ULPsTK_oHLGRa48lTWp3yO7JyovZs1oBZg3aP7gOU5J5Vavgd5vGx4fLVdJ6wcMe4Pn7TKE/s320/WaltK.jpg" width="320" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">The wry smile I remember so well. Vichnaya pamyat. August 14, 2021</td></tr></tbody></table><br /><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhhGjdpwFTjbwEgssbST3yNe_ojCX3WKfPIQtDQK55_Z4SN7CqmR-YKP4xGY6XTrIj17RyZHnsmA0bBVHilsIdQFoOTb691YnLpYlUt72y_nlbvf8bxjA2Gzwa3A9b8y78XZiA4P0lXdic/s1677/FamiliaKorzeniowski.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="999" data-original-width="1677" height="191" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhhGjdpwFTjbwEgssbST3yNe_ojCX3WKfPIQtDQK55_Z4SN7CqmR-YKP4xGY6XTrIj17RyZHnsmA0bBVHilsIdQFoOTb691YnLpYlUt72y_nlbvf8bxjA2Gzwa3A9b8y78XZiA4P0lXdic/s320/FamiliaKorzeniowski.jpg" width="320" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Me, Oksy, Dy circa 1985</td></tr></tbody></table><br /><div><br /></div>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-175295098848829352021-06-29T16:16:00.003+01:002021-06-29T16:16:48.108+01:00It's my birthday<p>It's my birthday and I'm not crying, but I never thought I'd be alive at 67. None of us who were around in the '70s thought we would be. Better to burn out than it is to rust. </p><p>But I don't feel rusty. Sometimes, I get a little creaky. Inside I'm 35 and always will be. But today, my biggest regret is not being able to use my free rail pass because of Covid-19 pandemic restrictions. At least I have both doses of the AZ vaccine in me, and I hope to get a mRNA booster later in the year. Then I will venture forth, not before. Until then, I will do a Dr Seuss...</p><p><br /></p><blockquote><p>“Why fit in when you were born to stand out?” </p></blockquote><blockquote><blockquote><p style="text-align: right;">- Dr. Seuss</p></blockquote></blockquote><p>What a long strange trip it's been. </p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-73706256492876157442021-05-31T14:30:00.000+01:002021-05-31T14:30:04.554+01:00Science<p>Science was very much a part of my life and still is. I trained in Biology and Chemistry with minors in politics (of all things) and anthropology. I completed University in three years instead of the traditional 4 because I was in a hurry to get to work. </p><p>My first job was as a research assistant at Rockefeller University in NYC. It had the highest concentration of Nobel Prize winners of any institution. I hated it. Backstabbing academia. Writing grant requests and grovelling for money. Sacrificing hundreds if not thousands of rats after stressing them to study how the brain works -- at a time when the movie <i>Ben</i> was released -- was stressful, to say the least. Nightmares, insomnia Sunday through Thursday every week. I couldn't wait to leave, yet I was running the lab and had several assistants myself. </p><p>Went from there to Roche Labs to work in a lab studying drug metabolism. Sacrificed many more rats and injected rabbits with antigen to manufacture antibodies to study as well. Couldn't work with the beagle dogs as they were testing carcinogens that cause breast cancer. I hated bench research. It was not at all as pure as I had envisioned. At Roche, we didn't have to write grant requests but we did have to justify our programs and publish or perish. I only stayed a year in that job before moving into the marketing area. </p><p>So, I was stunned to come across a <a href="https://www.jbc.org/action/showPdf?pii=S0021-9258%2817%2934211-4" target="_blank">paper</a> I'd written so long ago online. My name then was Daria Korzeniowski. As the junior member of the team, you got to write the first draft of the paper. Mine was published almost exactly as I had written it. Apparently, it is still thought of as a seminal work in the discovery of how p450 works. Well, I'll be! I suppose if I had stayed in science I might have achieved high ranks but I wouldn't have been President of companies nor an entrepreneur. </p><p>Did it work out well? You bet. I got to retire early and go sailing. What's wrong with that? </p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0tag:blogger.com,1999:blog-25393536747247227.post-80590206118340434522021-04-17T18:05:00.000+01:002021-04-17T18:05:03.679+01:00Coronavirus stats<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhC6o8zbdinyjz699O4FukIinBmTFZacomkpDVObDjeXKtczFdctLMnIWsM05ofHJRWwmOWmA_UrafLS32PqEwy2JJY6-mYnCCCT6OFMAs3LrzmM6AxEYlGQDqWTaE2Gz26noAZOuaZ5Sg/s800/00169805-800.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="450" data-original-width="800" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhC6o8zbdinyjz699O4FukIinBmTFZacomkpDVObDjeXKtczFdctLMnIWsM05ofHJRWwmOWmA_UrafLS32PqEwy2JJY6-mYnCCCT6OFMAs3LrzmM6AxEYlGQDqWTaE2Gz26noAZOuaZ5Sg/s320/00169805-800.jpg" width="320" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Funeral of Prince Philip</td></tr></tbody></table><div class="separator" style="clear: both; text-align: center;"><br /></div><p>I have not paid much attention to global coronavirus stats lately, only local ones. For several weeks, we had no cases in Westport, while we now have had 7 cases in the last 14 days. Today I noticed a headline that caused me to pause. The world had surpassed 3 million dead from this infection with more than 141,000,000 confirmed cases. That is astounding. </p><p>Tomorrow, I get to sign up for the vaccine. I will be getting the AstraZeneca version, an adenovirus vector surface protein vaccine. It's not the most effective and the clinical trials have been plagued by missteps, but it protects against severe infection and hospitalization, which counts for a lot. After vaccination, we won't be able to let down our guard, but at least we won't have to hold our breath anymore. Let's hope we don't suffer the rare blood clots associated with the disease, but this rare SE has been mostly associated with younger women. The risks of Covid far outweigh the risks of vaccination. When available, we'll get the Pfizer vaccine as a booster later on. </p><p>Several weeks ago, Alex's mother had a stroke that left her right side impaired. She was released from hospital where no one was permitted to visit her on Thursday. Alex and Kirstin are caring for her until Monday when a trained nurse (though not licensed here yet) from the Philippines will take over. She will be living in for 5 of 7 days. We need to find someone for the remaining two. We also have a physio, an occupational therapist, a podiatrist, her doctor and a nurse visiting. Meike has one dose of vaccine in her thank goodness. None of the others are vaccinated which worries me. </p><p>Today's Prince Philip the Duke of Edinborough was buried at Windsor. It was a remarkably simple but moving funeral. To see the Queen sitting alone in the pew was heartbreaking. Only the family could attend and they all had to sit in their family pods distanced from the others. </p><p>What a cruel time this has been. </p>Daria Blackwellhttp://www.blogger.com/profile/12400274355158993168noreply@blogger.com0